Disease-associated astrocytes in Alzheimer’s disease and aging

Naomi Habib*, Cristin McCabe, Sedi Medina, Miriam Varshavsky, Daniel Kitsberg, Raz Dvir-Szternfeld, Gilad Green, Danielle Dionne, Lan Nguyen, Jamie L. Marshall, Fei Chen, Feng Zhang, Tommy Kaplan, Aviv Regev, Michal Schwartz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

445 Scopus citations

Abstract

The role of non-neuronal cells in Alzheimer’s disease progression has not been fully elucidated. Using single-nucleus RNA sequencing, we identified a population of disease-associated astrocytes in an Alzheimer’s disease mouse model. These disease-associated astrocytes appeared at early disease stages and increased in abundance with disease progression. We discovered that similar astrocytes appeared in aged wild-type mice and in aging human brains, suggesting their linkage to genetic and age-related factors.

Original languageAmerican English
Pages (from-to)701-706
Number of pages6
JournalNature Neuroscience
Volume23
Issue number6
DOIs
StatePublished - 1 Jun 2020

Bibliographical note

Publisher Copyright:
© 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.

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