Disease-associated astrocytes in Alzheimer’s disease and aging

Naomi Habib; Cristin McCabe; Sedi Medina; Miriam Varshavsky; Daniel Kitsberg; Raz Dvir-Szternfeld; Gilad Green; Danielle Dionne; Lan Nguyen; Jamie L. Marshall; Fei Chen; Feng Zhang; Tommy Kaplan; Aviv Regev; Michal Schwartz

doi:10.1038/s41593-020-0624-8

Disease-associated astrocytes in Alzheimer’s disease and aging

Naomi Habib^*, Cristin McCabe, Sedi Medina, Miriam Varshavsky, Daniel Kitsberg, Raz Dvir-Szternfeld, Gilad Green, Danielle Dionne, Lan Nguyen, Jamie L. Marshall, Fei Chen, Feng Zhang, Tommy Kaplan, Aviv Regev, Michal Schwartz

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

477 Scopus citations

Abstract

The role of non-neuronal cells in Alzheimer’s disease progression has not been fully elucidated. Using single-nucleus RNA sequencing, we identified a population of disease-associated astrocytes in an Alzheimer’s disease mouse model. These disease-associated astrocytes appeared at early disease stages and increased in abundance with disease progression. We discovered that similar astrocytes appeared in aged wild-type mice and in aging human brains, suggesting their linkage to genetic and age-related factors.

Original language	English
Pages (from-to)	701-706
Number of pages	6
Journal	Nature Neuroscience
Volume	23
Issue number	6
DOIs	https://doi.org/10.1038/s41593-020-0624-8
State	Published - 1 Jun 2020

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Publisher Copyright:
© 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.

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title = "Disease-associated astrocytes in Alzheimer{\textquoteright}s disease and aging",

abstract = "The role of non-neuronal cells in Alzheimer{\textquoteright}s disease progression has not been fully elucidated. Using single-nucleus RNA sequencing, we identified a population of disease-associated astrocytes in an Alzheimer{\textquoteright}s disease mouse model. These disease-associated astrocytes appeared at early disease stages and increased in abundance with disease progression. We discovered that similar astrocytes appeared in aged wild-type mice and in aging human brains, suggesting their linkage to genetic and age-related factors.",

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AU - McCabe, Cristin

AU - Medina, Sedi

AU - Varshavsky, Miriam

AU - Kitsberg, Daniel

AU - Dvir-Szternfeld, Raz

AU - Green, Gilad

AU - Dionne, Danielle

AU - Nguyen, Lan

AU - Marshall, Jamie L.

AU - Chen, Fei

AU - Zhang, Feng

AU - Kaplan, Tommy

AU - Regev, Aviv

AU - Schwartz, Michal

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Disease-associated astrocytes in Alzheimer’s disease and aging

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