TY - JOUR
T1 - Disposition of sulfadimethoxine in cattle
T2 - Inclusion of protein binding factors in a pharmacokinetic model
AU - Bourne, D. W.A.
AU - Bialer, M.
AU - Dittert, L. W.
AU - Hayashi, M.
AU - Rudawsky, G.
AU - Koritz, G. D.
AU - Bevill, R. F.
PY - 1981/9
Y1 - 1981/9
N2 - Sulfadimethoxine was administered intravenously and orally to four cattle, and plasma and urine samples were collected at various times postdose. Modeling these data with a linear pharmacokinetic model gave unsatisfactory fits, and the data were subsequently fitted to a one‐compartment model with saturable protein binding. The saturable protein binding model included the usual linear excretion and elimination processes as well as protein binding parameters. The values obtained in vivo for the binding constant, 5.01 × 104 M−1, and the total protein concentration, 7.89 × 10−4 M, compared favorably with previously reported in vitro values. These results indicate that protein binding can be successfully included in a pharmacokinetic model.
AB - Sulfadimethoxine was administered intravenously and orally to four cattle, and plasma and urine samples were collected at various times postdose. Modeling these data with a linear pharmacokinetic model gave unsatisfactory fits, and the data were subsequently fitted to a one‐compartment model with saturable protein binding. The saturable protein binding model included the usual linear excretion and elimination processes as well as protein binding parameters. The values obtained in vivo for the binding constant, 5.01 × 104 M−1, and the total protein concentration, 7.89 × 10−4 M, compared favorably with previously reported in vitro values. These results indicate that protein binding can be successfully included in a pharmacokinetic model.
KW - Pharmacokinetics—sulfadimethoxine, protein binding, cattle
KW - Protein binding—sulfadimethoxine, pharmacokinetics, cattle
KW - Sulfadimethoxine—protein binding, pharmacokinetics, cattle
UR - http://www.scopus.com/inward/record.url?scp=0019828004&partnerID=8YFLogxK
U2 - 10.1002/jps.2600700926
DO - 10.1002/jps.2600700926
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C2 - 6101158
AN - SCOPUS:0019828004
SN - 0022-3549
VL - 70
SP - 1068
EP - 1072
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
IS - 9
ER -