Dissecting the cellular origins of pancreatic cancer

Ben Z. Stanger*, Yuval Dor

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations

Abstract

Although putative premalignant lesions like metaplasia - the replacement of one mature cell type with another - have been identified in a variety of cancers, the normal cellular targets of malignant transformation are largely unknown. Pancreatic ductal adenocarcinoma (PDAC) is a particularly aggressive and lethal cancer. Despite its ductal histology, however, it is unknown whether PDAC originates from pancreatic ducts or another cell type within the pancreas. Recent analysis of mice with pancreas-specific deletion of the PTEN tumor suppressor gene has provided new insight into the mechanism of metaplasia and focuses attention on pancreatic centroacinar cells as candidates for the cellular origin of PDAC. Characterization of the "cell-of-origin" could lead to a better understanding of the molecular substrate for tumor initiation and eventually to early diagnosis and treatment.

Original languageAmerican English
Pages (from-to)43-46
Number of pages4
JournalCell Cycle
Volume5
Issue number1
DOIs
StatePublished - 1 Jan 2006

Bibliographical note

Funding Information:
BZS is supported by NIH K08 DK064136.YD is supported by the Barbara S. Goodman ICRF RCDA.

Keywords

  • Cell-of-origin
  • Centroacinar cells
  • Development
  • Metaplasia
  • PI3-kinase
  • PTEN
  • Pancreatic cancer

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