Disseminated aspergillosis in association with Candida Glabrata infection in a Vizsla dog in Israel

A 5-year-old Vizsla female dog was presented with panuveitis and glaucoma two weeks subsequent to the left eye being enucleated due to a similar clinical manifestation. The dog was depressed, ataxic, had slow conscious proprioception in all four limbs, positional strabismus of the remaining eye and a lack of physiological nystagmus. Diffuse back pain was detected at the cranial thoracic vertebrae. Anatomic localization of the neurological signs was indicative of a multifocal lesion involving the cranial medulla, the first few segments of the spinal cord, the vertebral column and eyes. Infection of the central nervous system was suspected to be the basis of the clinical presentation. The dog was euthanized at the request of the owners. At gross pathology multifocal lesions were present in multiple organs. Histological examination revealed pyogranulomatous necrotizing changes in all of the organs with the presence of intralesional scant to moderate amount of fungal hyphae. A fungus was identified from the urine as Aspergillus terreus. Yeast was isolated from the stomach, esophagus and pancreas and identified as Candida glabrata. A diagnosis of disseminated aspergillosis in a Vizsla dog caused by A. terreus was made, combined with a Candida glabrata infection.