Disseminated Mycobacterium kansasii Infection With Pulmonary Alveolar Proteinosis in a Patient with Chronic Myelogenous Leukemia

Neta Goldschmidt, Samir Nusair*, Alexander Gural, Gail Amir, Uzi Izhar, Uri Laxer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

A 64-year-old woman with chronic myelogenous leukemia (CML) was admitted due to prolonged fever and lung infiltrates. An open lung biopsy was required to make the diagnosis of pulmonary alveolar proteinosis (PAP) and infection with Mycobacterium kansasii. She was treated successfully with combined antimycobacterial therapy for 14 months. However, the leukemia progressed and the patient developed recurrent bilateral lung infiltrates. Blood and bronchoalveolar fluid cultures yielded growth of Acinetobacter. She died shortly thereafter due to septic shock. The relationship between M. kansasii infection, PAP, and abnormal host defense in CML is discussed.

Original languageAmerican English
Pages (from-to)221-223
Number of pages3
JournalAmerican Journal of Hematology
Volume74
Issue number3
DOIs
StatePublished - Nov 2003
Externally publishedYes

Keywords

  • Chronic myelogenous leukemia
  • Granulocyte-macrophage colony-stimulating factor
  • Mycobacterium kansasii
  • Pulmonary alveolar proteinosis
  • Surfactant protein-A

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