Disseminated Mycobacterium kansasii Infection With Pulmonary Alveolar Proteinosis in a Patient with Chronic Myelogenous Leukemia

Neta Goldschmidt; Samir Nusair; Alexander Gural; Gail Amir; Uzi Izhar; Uri Laxer

doi:10.1002/ajh.10410

Disseminated Mycobacterium kansasii Infection With Pulmonary Alveolar Proteinosis in a Patient with Chronic Myelogenous Leukemia

Neta Goldschmidt, Samir Nusair^*, Alexander Gural, Gail Amir, Uzi Izhar, Uri Laxer

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A 64-year-old woman with chronic myelogenous leukemia (CML) was admitted due to prolonged fever and lung infiltrates. An open lung biopsy was required to make the diagnosis of pulmonary alveolar proteinosis (PAP) and infection with Mycobacterium kansasii. She was treated successfully with combined antimycobacterial therapy for 14 months. However, the leukemia progressed and the patient developed recurrent bilateral lung infiltrates. Blood and bronchoalveolar fluid cultures yielded growth of Acinetobacter. She died shortly thereafter due to septic shock. The relationship between M. kansasii infection, PAP, and abnormal host defense in CML is discussed.

Original language	English
Pages (from-to)	221-223
Number of pages	3
Journal	American Journal of Hematology
Volume	74
Issue number	3
DOIs	https://doi.org/10.1002/ajh.10410
State	Published - Nov 2003
Externally published	Yes

Keywords

Chronic myelogenous leukemia
Granulocyte-macrophage colony-stimulating factor
Mycobacterium kansasii
Pulmonary alveolar proteinosis
Surfactant protein-A

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ajh.10410

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title = "Disseminated Mycobacterium kansasii Infection With Pulmonary Alveolar Proteinosis in a Patient with Chronic Myelogenous Leukemia",

abstract = "A 64-year-old woman with chronic myelogenous leukemia (CML) was admitted due to prolonged fever and lung infiltrates. An open lung biopsy was required to make the diagnosis of pulmonary alveolar proteinosis (PAP) and infection with Mycobacterium kansasii. She was treated successfully with combined antimycobacterial therapy for 14 months. However, the leukemia progressed and the patient developed recurrent bilateral lung infiltrates. Blood and bronchoalveolar fluid cultures yielded growth of Acinetobacter. She died shortly thereafter due to septic shock. The relationship between M. kansasii infection, PAP, and abnormal host defense in CML is discussed.",

keywords = "Chronic myelogenous leukemia, Granulocyte-macrophage colony-stimulating factor, Mycobacterium kansasii, Pulmonary alveolar proteinosis, Surfactant protein-A",

author = "Neta Goldschmidt and Samir Nusair and Alexander Gural and Gail Amir and Uzi Izhar and Uri Laxer",

year = "2003",

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T1 - Disseminated Mycobacterium kansasii Infection With Pulmonary Alveolar Proteinosis in a Patient with Chronic Myelogenous Leukemia

AU - Goldschmidt, Neta

AU - Nusair, Samir

AU - Gural, Alexander

AU - Amir, Gail

AU - Izhar, Uzi

AU - Laxer, Uri

PY - 2003/11

Y1 - 2003/11

N2 - A 64-year-old woman with chronic myelogenous leukemia (CML) was admitted due to prolonged fever and lung infiltrates. An open lung biopsy was required to make the diagnosis of pulmonary alveolar proteinosis (PAP) and infection with Mycobacterium kansasii. She was treated successfully with combined antimycobacterial therapy for 14 months. However, the leukemia progressed and the patient developed recurrent bilateral lung infiltrates. Blood and bronchoalveolar fluid cultures yielded growth of Acinetobacter. She died shortly thereafter due to septic shock. The relationship between M. kansasii infection, PAP, and abnormal host defense in CML is discussed.

AB - A 64-year-old woman with chronic myelogenous leukemia (CML) was admitted due to prolonged fever and lung infiltrates. An open lung biopsy was required to make the diagnosis of pulmonary alveolar proteinosis (PAP) and infection with Mycobacterium kansasii. She was treated successfully with combined antimycobacterial therapy for 14 months. However, the leukemia progressed and the patient developed recurrent bilateral lung infiltrates. Blood and bronchoalveolar fluid cultures yielded growth of Acinetobacter. She died shortly thereafter due to septic shock. The relationship between M. kansasii infection, PAP, and abnormal host defense in CML is discussed.

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KW - Granulocyte-macrophage colony-stimulating factor

KW - Mycobacterium kansasii

KW - Pulmonary alveolar proteinosis

KW - Surfactant protein-A

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Disseminated Mycobacterium kansasii Infection With Pulmonary Alveolar Proteinosis in a Patient with Chronic Myelogenous Leukemia

Abstract

Keywords

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