TY - JOUR
T1 - Disseminated thrombosis-induced growth plate necrosis in rat
T2 - A unique model for growth plate arrest
AU - Nyska, Meir
AU - Shabat, Shay
AU - Long, Philip H.
AU - Howard, Charles
AU - Ezov, Nathan
AU - Levin-Harrus, Tal
AU - Mittelman, Moshe
AU - Redlich, Meir
AU - Yedgar, Saul
AU - Nyska, Abraham
PY - 2005/5
Y1 - 2005/5
N2 - Exposure of rats to 2-butoxyethanol (BE) produces early hemolytic anemia and disseminated thrombosis. This leads to infarctions in multiple organs, including bones and cartilage. BE, administered for different durations of exposure in two separate experiments, produced metaphyseal vascular thrombosis, growth plate infarction, and partial or complete physeal growth arrest. This reproducible model may serve as a useful tool in the study of some conditions that manifest growth plate damage. The suitability of this model for investigating the pathogenesis of growth plate necrosis and as a model for potential therapy for various human growth plate disorders are discussed.
AB - Exposure of rats to 2-butoxyethanol (BE) produces early hemolytic anemia and disseminated thrombosis. This leads to infarctions in multiple organs, including bones and cartilage. BE, administered for different durations of exposure in two separate experiments, produced metaphyseal vascular thrombosis, growth plate infarction, and partial or complete physeal growth arrest. This reproducible model may serve as a useful tool in the study of some conditions that manifest growth plate damage. The suitability of this model for investigating the pathogenesis of growth plate necrosis and as a model for potential therapy for various human growth plate disorders are discussed.
KW - 2-butoxtethanol
KW - Physeal growth arrest
KW - Rat model
KW - Thrombosis
UR - http://www.scopus.com/inward/record.url?scp=17844378938&partnerID=8YFLogxK
U2 - 10.1097/01.bpo.0000153878.28185.2a
DO - 10.1097/01.bpo.0000153878.28185.2a
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C2 - 15832152
AN - SCOPUS:17844378938
SN - 0271-6798
VL - 25
SP - 346
EP - 350
JO - Journal of Pediatric Orthopaedics
JF - Journal of Pediatric Orthopaedics
IS - 3
ER -