Disseminated thrombosis-induced growth plate necrosis in rat: A unique model for growth plate arrest

Meir Nyska*, Shay Shabat, Philip H. Long, Charles Howard, Nathan Ezov, Tal Levin-Harrus, Moshe Mittelman, Meir Redlich, Saul Yedgar, Abraham Nyska

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Exposure of rats to 2-butoxyethanol (BE) produces early hemolytic anemia and disseminated thrombosis. This leads to infarctions in multiple organs, including bones and cartilage. BE, administered for different durations of exposure in two separate experiments, produced metaphyseal vascular thrombosis, growth plate infarction, and partial or complete physeal growth arrest. This reproducible model may serve as a useful tool in the study of some conditions that manifest growth plate damage. The suitability of this model for investigating the pathogenesis of growth plate necrosis and as a model for potential therapy for various human growth plate disorders are discussed.

Original languageEnglish
Pages (from-to)346-350
Number of pages5
JournalJournal of Pediatric Orthopaedics
Volume25
Issue number3
DOIs
StatePublished - May 2005

Keywords

  • 2-butoxtethanol
  • Physeal growth arrest
  • Rat model
  • Thrombosis

Fingerprint

Dive into the research topics of 'Disseminated thrombosis-induced growth plate necrosis in rat: A unique model for growth plate arrest'. Together they form a unique fingerprint.

Cite this