Disseminated thrombosis-induced growth plate necrosis in rat: A unique model for growth plate arrest

Meir Nyska; Shay Shabat; Philip H. Long; Charles Howard; Nathan Ezov; Tal Levin-Harrus; Moshe Mittelman; Meir Redlich; Saul Yedgar; Abraham Nyska

doi:10.1097/01.bpo.0000153878.28185.2a

Disseminated thrombosis-induced growth plate necrosis in rat: A unique model for growth plate arrest

Meir Nyska^*
, Shay Shabat
, Philip H. Long
, Charles Howard
, Nathan Ezov
, Tal Levin-Harrus
, Moshe Mittelman
, Meir Redlich
, Saul Yedgar
, Abraham Nyska

^*Corresponding author for this work

Department of Biochemistry and Molecular Biology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Exposure of rats to 2-butoxyethanol (BE) produces early hemolytic anemia and disseminated thrombosis. This leads to infarctions in multiple organs, including bones and cartilage. BE, administered for different durations of exposure in two separate experiments, produced metaphyseal vascular thrombosis, growth plate infarction, and partial or complete physeal growth arrest. This reproducible model may serve as a useful tool in the study of some conditions that manifest growth plate damage. The suitability of this model for investigating the pathogenesis of growth plate necrosis and as a model for potential therapy for various human growth plate disorders are discussed.

Original language	English
Pages (from-to)	346-350
Number of pages	5
Journal	Journal of Pediatric Orthopaedics
Volume	25
Issue number	3
DOIs	https://doi.org/10.1097/01.bpo.0000153878.28185.2a
State	Published - May 2005

Keywords

2-butoxtethanol
Physeal growth arrest
Rat model
Thrombosis

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10.1097/01.bpo.0000153878.28185.2a

Cite this

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title = "Disseminated thrombosis-induced growth plate necrosis in rat: A unique model for growth plate arrest",

abstract = "Exposure of rats to 2-butoxyethanol (BE) produces early hemolytic anemia and disseminated thrombosis. This leads to infarctions in multiple organs, including bones and cartilage. BE, administered for different durations of exposure in two separate experiments, produced metaphyseal vascular thrombosis, growth plate infarction, and partial or complete physeal growth arrest. This reproducible model may serve as a useful tool in the study of some conditions that manifest growth plate damage. The suitability of this model for investigating the pathogenesis of growth plate necrosis and as a model for potential therapy for various human growth plate disorders are discussed.",

keywords = "2-butoxtethanol, Physeal growth arrest, Rat model, Thrombosis",

author = "Meir Nyska and Shay Shabat and Long, \{Philip H.\} and Charles Howard and Nathan Ezov and Tal Levin-Harrus and Moshe Mittelman and Meir Redlich and Saul Yedgar and Abraham Nyska",

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T1 - Disseminated thrombosis-induced growth plate necrosis in rat

T2 - A unique model for growth plate arrest

AU - Nyska, Meir

AU - Shabat, Shay

AU - Long, Philip H.

AU - Howard, Charles

AU - Ezov, Nathan

AU - Levin-Harrus, Tal

AU - Mittelman, Moshe

AU - Redlich, Meir

AU - Yedgar, Saul

AU - Nyska, Abraham

PY - 2005/5

Y1 - 2005/5

N2 - Exposure of rats to 2-butoxyethanol (BE) produces early hemolytic anemia and disseminated thrombosis. This leads to infarctions in multiple organs, including bones and cartilage. BE, administered for different durations of exposure in two separate experiments, produced metaphyseal vascular thrombosis, growth plate infarction, and partial or complete physeal growth arrest. This reproducible model may serve as a useful tool in the study of some conditions that manifest growth plate damage. The suitability of this model for investigating the pathogenesis of growth plate necrosis and as a model for potential therapy for various human growth plate disorders are discussed.

AB - Exposure of rats to 2-butoxyethanol (BE) produces early hemolytic anemia and disseminated thrombosis. This leads to infarctions in multiple organs, including bones and cartilage. BE, administered for different durations of exposure in two separate experiments, produced metaphyseal vascular thrombosis, growth plate infarction, and partial or complete physeal growth arrest. This reproducible model may serve as a useful tool in the study of some conditions that manifest growth plate damage. The suitability of this model for investigating the pathogenesis of growth plate necrosis and as a model for potential therapy for various human growth plate disorders are discussed.

KW - 2-butoxtethanol

KW - Physeal growth arrest

KW - Rat model

KW - Thrombosis

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JF - Journal of Pediatric Orthopaedics

IS - 3

ER -

Disseminated thrombosis-induced growth plate necrosis in rat: A unique model for growth plate arrest

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Keywords

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