Dissociation of interferon effects on murine leukemia virus and encephalomyocarditis virus replication in mouse cells

C. W. Czarniecki, T. Sreevalsan, R. M. Friedman, A. Panet

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Two subclones of Swiss mouse cells infected with Moloney murine leukemia virus (M-MuLV) were tested for their response to interferon (IFN). Whereas M-MuLV production in the two subclones was inhibited to the same extent, one of the subclones was significantly more sensitive to IFN when the antiviral effect was measured by replication of encephalomyocarditis (EMC) virus. The same subclone was also more sensitive to the anticellular activities of IFN. Additionally, NIH 3T3 cells infected with M-MuLV were completely resistant to IFN actions when EMC virus replication or the anticellular activities were tested. However, under the same conditions, M-MuLV production was completely inhibited by IFN. These results indicate that IFN may effect cell growth functions and EMC replication through mechanisms different from those by which MuLV production is inhibited.

Original languageEnglish
Pages (from-to)827-831
Number of pages5
JournalJournal of Virology
Volume37
Issue number2
DOIs
StatePublished - 1981
Externally publishedYes

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