Distinct roles of TET-mediated cytosine oxidation in neural stem cell fate decisions

Oren Ram

doi:10.1016/j.stemcr.2025.102614

Distinct roles of TET-mediated cytosine oxidation in neural stem cell fate decisions

Oren Ram^*

^*Corresponding author for this work

Department of Biological Chemistry

Research output: Contribution to journal › Comment/debate

Abstract

Ten-eleven translocation (TET) enzymes regulate neural stem cell development via distinct cytosine oxidation steps. This study, by Ebert et al. reveals that hydroxymethylation is crucial for neurogenesis, while formylation and carboxylation drive gliogenesis, offering insights into TET biology and therapeutic potential in neurodevelopmental and neurodegenerative disorders.

Original language	English
Article number	102614
Journal	Stem Cell Reports
Volume	20
Issue number	9
DOIs	https://doi.org/10.1016/j.stemcr.2025.102614
State	Published - 9 Sep 2025

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© 2025 The Author(s)

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10.1016/j.stemcr.2025.102614

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abstract = "Ten-eleven translocation (TET) enzymes regulate neural stem cell development via distinct cytosine oxidation steps. This study, by Ebert et al. reveals that hydroxymethylation is crucial for neurogenesis, while formylation and carboxylation drive gliogenesis, offering insights into TET biology and therapeutic potential in neurodevelopmental and neurodegenerative disorders.",

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Distinct roles of TET-mediated cytosine oxidation in neural stem cell fate decisions

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