TY - JOUR
T1 - Distinct transmission cycles of Leishmania tropica in 2 adjacent foci, northern Israel
AU - Svobodova, Milena
AU - Votypka, Jan
AU - Peckova, Jitka
AU - Dvorak, Vít
AU - Nasereddin, Abedelmajeed
AU - Baneth, Gad
AU - Sztern, Julia
AU - Kravchenko, Vasiliy
AU - Orr, Amnon
AU - Meir, David
AU - Schnur, Lionel F.
AU - Volf, Petr
AU - Warburg, Alon
PY - 2006/12
Y1 - 2006/12
N2 - Transmission of Leishmania tropica was studied in 2 adjacent foci in Israel where vector populations differ. Only Phlebotomus sergenti was found infected with L. tropica in the southern focus; P. arabicus was the main vector in the northern focus. Rock hyraxes (Procavia capensis) were incriminated as reservoir hosts in both foci. L. tropica strains from the northern focus isolated from sand flies, cutaneous leishmaniasis cases, and rock hyraxes were antigenically similar to L. major, and strains from the southern focus were typically L. tropica. Laboratory studies showed that P. arabicus is a competent vector of L. tropica, and P. sergenti is essentially refractory to L. tropica from the northern focus. Susceptibility of P. arabicus may be mediated by O glycoproteins on the luminal surface of its midgut. The 2 foci differ with respect to parasites and vectors, but increasing peridomestic rock hyrax populations are probably responsible for emergence of cutaneous leishmaniasis in both foci.
AB - Transmission of Leishmania tropica was studied in 2 adjacent foci in Israel where vector populations differ. Only Phlebotomus sergenti was found infected with L. tropica in the southern focus; P. arabicus was the main vector in the northern focus. Rock hyraxes (Procavia capensis) were incriminated as reservoir hosts in both foci. L. tropica strains from the northern focus isolated from sand flies, cutaneous leishmaniasis cases, and rock hyraxes were antigenically similar to L. major, and strains from the southern focus were typically L. tropica. Laboratory studies showed that P. arabicus is a competent vector of L. tropica, and P. sergenti is essentially refractory to L. tropica from the northern focus. Susceptibility of P. arabicus may be mediated by O glycoproteins on the luminal surface of its midgut. The 2 foci differ with respect to parasites and vectors, but increasing peridomestic rock hyrax populations are probably responsible for emergence of cutaneous leishmaniasis in both foci.
UR - http://www.scopus.com/inward/record.url?scp=33845423947&partnerID=8YFLogxK
U2 - 10.3201/eid1212.060497
DO - 10.3201/eid1212.060497
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C2 - 17326936
AN - SCOPUS:33845423947
SN - 1080-6040
VL - 12
SP - 1860
EP - 1868
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 12
ER -