TY - JOUR
T1 - Distribution of amphotericin B-arabinogalactan conjugate in mouse tissue and its therapeutic efficacy against murine aspergillosis
AU - Falk, Rama
AU - Grunwald, Jacob
AU - Hoffman, Amnon
AU - Domb, Abraham J.
AU - Polacheck, Itzhack
PY - 2004/9
Y1 - 2004/9
N2 - The pharmacokinetic characteristics and tissue distribution of a novel water-soluble, nontoxic amphotericin B-arabinogalactan (AMB-AG) conjugate exhibited distinct differences from those of micellar and liposomal amphotericin B formulations. These differences included extended persistence of drug in the body and its accumulation in the lungs; thus, the AMB-AG conjugate was highly effective in treating systemic murine aspergillosis.
AB - The pharmacokinetic characteristics and tissue distribution of a novel water-soluble, nontoxic amphotericin B-arabinogalactan (AMB-AG) conjugate exhibited distinct differences from those of micellar and liposomal amphotericin B formulations. These differences included extended persistence of drug in the body and its accumulation in the lungs; thus, the AMB-AG conjugate was highly effective in treating systemic murine aspergillosis.
UR - http://www.scopus.com/inward/record.url?scp=4344606417&partnerID=8YFLogxK
U2 - 10.1128/AAC.48.9.3606-3609.2004
DO - 10.1128/AAC.48.9.3606-3609.2004
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C2 - 15328139
AN - SCOPUS:4344606417
SN - 0066-4804
VL - 48
SP - 3606
EP - 3609
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 9
ER -