Diversification of neurotoxins by C-tail 'wiggling': A scorpion recipe for survival

Michael Gurevitz*, Dalia Gordon, Sharon Ben-Natan, Michael Turkov, Oren Froy

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

The structure of bioactive surfaces of proteins is a subject of intensive research, yet the mechanisms by which such surfaces have evolved are largely unknown. Polypeptide toxins produced by venomous animals such as sea anemones, cone snails, scorpions, and snakes show multiple routes for active site diversification, each maintaining a typical conserved scaffold. Comparative analysis of an array of genetically related scorpion polypeptide toxins that modulate sodium channels in neuronal membranes suggests a unique route of toxic site diversification. This premise is based on recent identification of bioactive surfaces of toxin representative of three distinct pharmacological groups and a comparison of their 3-dimensional structures. Despite their similar scaffold, the bioactive surfaces of the various toxins vary cousiderably, but always coincide with the molecular exterior onto which the C-tail is anchored. Superposition of the toxin structures indicates that the C-tails diverge from a common structural start point, which suggests that the pharmacological versatility displayed by these toxins might have been achieved along evolution via structural reconfiguration of the C-tail, leading to reshaping of new bioactive surfaces. - Gurevitz, M., Gordon, D., Ben-Natan, S., Turkov, M., Froy, O. Diversification of neurotoxins by C-tail 'wiggling': a scorpion recipe for survival.

Original languageAmerican English
Pages (from-to)1201-1205
Number of pages5
JournalFASEB Journal
Volume15
Issue number7
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Bioactive surface
  • Scorpion neurotoxin
  • Toxic polypeptides

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