Abstract
Six substituted DL-α-trimethylsilylphenyl-β-hydroxypropionic acids were prepared starting from sodium p- or m-trimethylsilylphenylacetate which was converted to the Ivanov reagent with isopropylmagnesium chloride and treated with aldehydes or ketones. β-N,N-Dimethyl- and β-N,N-diethylaminoethyl esters were prepared from the acids with the corresponding β-N,N-dialkylaminoethyl chloride in boiling 2-propanol. Preliminary pharmacological evaluation showed that these esters have anticholinergic activity and some of them have protective effects against organophosphate poisoning.
Original language | English |
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Pages (from-to) | 448-450 |
Number of pages | 3 |
Journal | Journal of Medicinal Chemistry |
Volume | 11 |
Issue number | 3 |
DOIs | |
State | Published - 1 Mar 1968 |