DL-β-N,N-dialkylaminoethyl Esters of Substituted α-Trimethylsilylphenyl-β-hydroxypropionic Acids

Six substituted DL-α-trimethylsilylphenyl-β-hydroxypropionic acids were prepared starting from sodium p- or m-trimethylsilylphenylacetate which was converted to the Ivanov reagent with isopropylmagnesium chloride and treated with aldehydes or ketones. β-N,N-Dimethyl- and β-N,N-diethylaminoethyl esters were prepared from the acids with the corresponding β-N,N-dialkylaminoethyl chloride in boiling 2-propanol. Preliminary pharmacological evaluation showed that these esters have anticholinergic activity and some of them have protective effects against organophosphate poisoning.