DMAP-assisted sulfonylation as an efficient step for the methylation of primary amine motifs on solid support

Keyphrases

• Methylation 100%
• Solid Support 100%
• Primary Amines 100%
• Sulfonylation 100%
• N-methylation 50%
• Collidine 50%
• Energy Barrier 25%
• High Efficiency 25%
• DFT Calculations 25%
• Amines 25%
• State-of-the-art Techniques 25%
• Regioselectivity 25%
• Solid-phase Synthesis 25%
• Nucleophilic 25%
• Methylation Site 25%
• Somatostatin Analogs 25%
• Activating Groups 25%
• Methylation of Amine 25%
• Multi-step Strategy 25%

Chemistry

• Primary Amine 100%
• Sulfonylation 100%
• methylation 100%
• Base 50%
• N-methylation 50%
• Energy Barrier 25%
• Somatostatin Analog 25%
• Density Functional Theory 25%

Biochemistry, Genetics and Molecular Biology

• Methylation 100%
• Solid Phase Synthesis 20%
• Nucleophilicity 20%
• Somatostatin Analog 20%