DNA fingerprint bands applied to linkage analysis with quantitative trait loci in chickens

Y. Plotsky, A. Cahaner, A. Haberfeld, J. Hillel, U. Lavi, S. J. Lamont*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Summary An efficient approach to detect association between quantitative traits and bands of DNA fingerprint patterns uses intra‐family tail analysis, which compares fingerprints of DNA mixes from individuals at the two tails of a phenotypic distribution. In analysis of 67 paternal half‐sibs of a meat‐type chicken family, of 57 sire bands generated by two probes, one sire‐specific band (S6–6) was associated with abdominal fat deposition. The band effect was estimated by a linear model analysis to be 0–88 standard deviations, or about 30% of the family mean. The association between band S6–6 and abdominal fat was further examined by testing progeny of paternal half‐sibs of the chickens which were used in the tail analysis, establishing genetic linkage between the DNA marker and a genetic locus affecting abdominal fat deposition.

Original languageEnglish
Pages (from-to)105-110
Number of pages6
JournalAnimal Genetics
Volume24
Issue number2
DOIs
StatePublished - Apr 1993

Keywords

  • DNA fingerprints
  • genetic markers
  • linear model
  • quantitative trait loci
  • tail analysis

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