Abstract
The assembly of adenosine triphosphate (ATP)-responsive and miRNA-responsive DNA tetrahedra-functionalized carboxymethyl cellulose hydrogel microcapsules is presented. The microcapsules are loaded with the doxorubicin-dextran drug or with CdSe/ZnS quantum dots as a drug model. Selective unlocking of the respective microcapsules and the release of the loads in the presence of ATP or miRNA-141 are demonstrated. Functionalization of the hydrogel microcapsules a with corona of DNA tetrahedra nanostructures yields microcarriers that revealed superior permeation into cells. This is demonstrated by the effective permeation of the DNA tetrahedra-functionalized microcapsules into MDA-MB-231 breast cancer cells, as compared to epithelial MCF-10A nonmalignant breast cells. The superior permeation of the tetrahedra-functionalized microcapsules into MDA-MB-231 breast cancer cells, as compared to analog control hydrogel microcapsules modified with a corona of nucleic acid duplexes. The effective permeation of the stimuli-responsive, drug-loaded, DNA tetrahedra-modified microcapsules yields drug carriers of superior and selective cytotoxicity toward cancer cells.
Original language | American English |
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Article number | 2204108 |
Journal | Small |
Volume | 18 |
Issue number | 52 |
DOIs | |
State | Published - 28 Dec 2022 |
Bibliographical note
Funding Information:This study is supported by ISF-Precision Medicine Program grant no. 1696/20, and the Ministry of Innovation, Science and Technology, Israel.
Funding Information:
This study is supported by ISF‐Precision Medicine Program grant no. 1696/20, and the Ministry of Innovation, Science and Technology, Israel.
Publisher Copyright:
© 2022 Wiley-VCH GmbH.
Keywords
- cancer
- controlled release
- doxorubicin
- drug delivery
- quantum dots