DNAM-1: An amplifier of immune responses as a therapeutic target in various disorders

M. Elishmereni, I. Bachelet, F. Levi-Schaffer*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

The co-stimulatory adhesion molecule DNAX accessory molecule 1 (DNAM-1) is a functional glycoprotein expressed on immune cells, such as natural killer and T-cells. It is activated upon interaction with its biological ligands, the poliovirus receptor and nectin-2. Signaling cascades involving stimulation of DNAM-1 lead to various biological responses, including target cell lysis and immune cell activation. Thus, DNAM-1 appears to be an integral molecule in immune responses in cancer, allergic inflammatory disorders and autoimmune diseases. The structure of DNAM-1, its mechanism of action and its effects in pathological scenarios are discussed.

Original languageAmerican English
Pages (from-to)491-496
Number of pages6
JournalCurrent Opinion in Investigational Drugs
Volume9
Issue number5
StatePublished - May 2008

Keywords

  • Adhesion molecule
  • Allergic inflammation
  • Cancer
  • Co-stimulatory molecule
  • Glycoprotein

Fingerprint

Dive into the research topics of 'DNAM-1: An amplifier of immune responses as a therapeutic target in various disorders'. Together they form a unique fingerprint.

Cite this