TY - JOUR
T1 - DNAM-1
T2 - An amplifier of immune responses as a therapeutic target in various disorders
AU - Elishmereni, M.
AU - Bachelet, I.
AU - Levi-Schaffer, F.
PY - 2008/5
Y1 - 2008/5
N2 - The co-stimulatory adhesion molecule DNAX accessory molecule 1 (DNAM-1) is a functional glycoprotein expressed on immune cells, such as natural killer and T-cells. It is activated upon interaction with its biological ligands, the poliovirus receptor and nectin-2. Signaling cascades involving stimulation of DNAM-1 lead to various biological responses, including target cell lysis and immune cell activation. Thus, DNAM-1 appears to be an integral molecule in immune responses in cancer, allergic inflammatory disorders and autoimmune diseases. The structure of DNAM-1, its mechanism of action and its effects in pathological scenarios are discussed.
AB - The co-stimulatory adhesion molecule DNAX accessory molecule 1 (DNAM-1) is a functional glycoprotein expressed on immune cells, such as natural killer and T-cells. It is activated upon interaction with its biological ligands, the poliovirus receptor and nectin-2. Signaling cascades involving stimulation of DNAM-1 lead to various biological responses, including target cell lysis and immune cell activation. Thus, DNAM-1 appears to be an integral molecule in immune responses in cancer, allergic inflammatory disorders and autoimmune diseases. The structure of DNAM-1, its mechanism of action and its effects in pathological scenarios are discussed.
KW - Adhesion molecule
KW - Allergic inflammation
KW - Cancer
KW - Co-stimulatory molecule
KW - Glycoprotein
UR - http://www.scopus.com/inward/record.url?scp=43549105875&partnerID=8YFLogxK
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C2 - 18465659
AN - SCOPUS:43549105875
SN - 1472-4472
VL - 9
SP - 491
EP - 496
JO - Current Opinion in Investigational Drugs
JF - Current Opinion in Investigational Drugs
IS - 5
ER -
