Abstract
The co-stimulatory adhesion molecule DNAX accessory molecule 1 (DNAM-1) is a functional glycoprotein expressed on immune cells, such as natural killer and T-cells. It is activated upon interaction with its biological ligands, the poliovirus receptor and nectin-2. Signaling cascades involving stimulation of DNAM-1 lead to various biological responses, including target cell lysis and immune cell activation. Thus, DNAM-1 appears to be an integral molecule in immune responses in cancer, allergic inflammatory disorders and autoimmune diseases. The structure of DNAM-1, its mechanism of action and its effects in pathological scenarios are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 491-496 |
| Number of pages | 6 |
| Journal | Current Opinion in Investigational Drugs |
| Volume | 9 |
| Issue number | 5 |
| State | Published - May 2008 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Keywords
- Adhesion molecule
- Allergic inflammation
- Cancer
- Co-stimulatory molecule
- Glycoprotein
Fingerprint
Dive into the research topics of 'DNAM-1: An amplifier of immune responses as a therapeutic target in various disorders'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver