DNAzyme-Like Activity of Hemin-Telomeric G-Quadruplexes for the Optical Analysis of Telomerase and its Inhibitors

Ronit Freeman, Etery Sharon, Carsten Teller, Anja Henning, Yehuda Tzfati, Itamar Willner*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

An escape from the TRAP: Telomere chains self-assemble into catalytically active hemin-G-quadruplex units. We describe how the resulting DNAzyme units can be used for quantitative analysis of telomerase activity and its inhibitors.

Original languageEnglish
Pages (from-to)2362-2367
Number of pages6
JournalChemBioChem
Volume11
Issue number17
DOIs
StatePublished - Nov 2010

Keywords

  • DNAzymes
  • G-quadruplexes
  • Inhibitors
  • Telomerase
  • Telomeres

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