DNAzyme-Like Activity of Hemin-Telomeric G-Quadruplexes for the Optical Analysis of Telomerase and its Inhibitors

Ronit Freeman; Etery Sharon; Carsten Teller; Anja Henning; Yehuda Tzfati; Itamar Willner

doi:10.1002/cbic.201000512

DNAzyme-Like Activity of Hemin-Telomeric G-Quadruplexes for the Optical Analysis of Telomerase and its Inhibitors

Ronit Freeman
, Etery Sharon
, Carsten Teller
, Anja Henning
, Yehuda Tzfati
, Itamar Willner^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

An escape from the TRAP: Telomere chains self-assemble into catalytically active hemin-G-quadruplex units. We describe how the resulting DNAzyme units can be used for quantitative analysis of telomerase activity and its inhibitors.

Original language	English
Pages (from-to)	2362-2367
Number of pages	6
Journal	ChemBioChem
Volume	11
Issue number	17
DOIs	https://doi.org/10.1002/cbic.201000512
State	Published - Nov 2010

Keywords

DNAzymes
G-quadruplexes
Inhibitors
Telomerase
Telomeres

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10.1002/cbic.201000512

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abstract = "An escape from the TRAP: Telomere chains self-assemble into catalytically active hemin-G-quadruplex units. We describe how the resulting DNAzyme units can be used for quantitative analysis of telomerase activity and its inhibitors.",

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author = "Ronit Freeman and Etery Sharon and Carsten Teller and Anja Henning and Yehuda Tzfati and Itamar Willner",

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AU - Teller, Carsten

AU - Henning, Anja

AU - Tzfati, Yehuda

AU - Willner, Itamar

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KW - G-quadruplexes

KW - Inhibitors

KW - Telomerase

KW - Telomeres

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DNAzyme-Like Activity of Hemin-Telomeric G-Quadruplexes for the Optical Analysis of Telomerase and its Inhibitors

Abstract

Keywords

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