Do more complex organisms have a greater proportion of membrane proteins in their genomes?

Timothy J. Stevens, Isaiah T. Arkin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

217 Scopus citations

Abstract

One may speculate that higher organisms require a proportionately greater abundance of membrane proteins within their genomes in order to furnish the requirements of differentiated cell types, compartmentalization, and intercellular signalling. With the recent availability of several complete prokaryotic genome sequences and sufficient progress in many eukaryotic genome sequencing projects, we seek to test this hypothesis. Using optimized hydropathy analysis of proteins in several, diverse proteomes, we show that organisms of the three domains of life - Eukarya, Eubacteria, and Archaea - have similar proportions of α-helical membrane proteins within their genomes and that these are matched by the complexity of the aqueous components. (C) 2000 Wiley-Liss, Inc.

Original languageAmerican English
Pages (from-to)417-420
Number of pages4
JournalProteins: Structure, Function and Genetics
Volume39
Issue number4
DOIs
StatePublished - 1 Jun 2000
Externally publishedYes

Keywords

  • Hydropathy
  • Hydrophobicity
  • Protein sequence
  • Proteome
  • α-helix

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