Does short-term diet restriction in mice precipitate the development of anorexia?

Omer Bonne*, Yosepha Avraham, Eitan Bachar, Maor Katz, Elliot M. Berry

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Anorexia nervosa (AN) inevitably begins with dieting. Yet, it is unknown whether anyone who will ultimately suffer from anorexia is already ill upon "going on a diet", or whether disease begins during, and is perhaps triggered by, dieting. The objective of the following study was to precipitate anorexia by imposing diet restriction on animals, as a model for generating AN in humans. Three hundred young female Sabra mice were diet restricted to 40% of daily nutrient requirements for 12 days, lost 17% of body weight and were then re-fed ad-lib. All mice regained appetite and weight. Our conclusions are that diet restriction does not precipitate anorexia in mice. Our findings do not support a role for diet restriction per se in triggering AN.

Original languageAmerican English
Pages (from-to)197-199
Number of pages3
JournalNutritional Neuroscience
Issue number3
StatePublished - Jun 2003


  • Anorexia
  • Mice
  • Serotonin
  • Short term diet restriction


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