TY - JOUR
T1 - Dopamine-, L-DOPA-, adrenaline-, and noradrenaline-induced growth of Au nanoparticles
T2 - Assays for the detection of neurotransmitters and of tyrosinase activity
AU - Baron, Ronan
AU - Zayats, Maya
AU - Willner, Itamar
PY - 2005/3/15
Y1 - 2005/3/15
N2 - The neurotransmitters dopamine (1), L-DOPA (2), adrenaline (3), and noradrenaline (4) mediate the generation and growth of Au nanoparticles (Au-NPs). The plasmon absorbance of the Au-NPs allows the quantitative colorimetric detection of the neurotransmitters. Neurotransmitters 1, 2, and 4 are sensed with a detection limit of 2.5 × 10-6 M, whereas the detection limit for analyzing 3 corresponds to 2 × 10-5 M. The neurotransmitter-mediated growth of the Au-NPs is also used to probe the activity of tyrosinase. The later biocatalyst oxidizes tyrosine to L-DOPA that mediates the growth of the Au-NPs. The analysis of tyrosinase activity is important for detecting melanoma cells and Parkinson disease.
AB - The neurotransmitters dopamine (1), L-DOPA (2), adrenaline (3), and noradrenaline (4) mediate the generation and growth of Au nanoparticles (Au-NPs). The plasmon absorbance of the Au-NPs allows the quantitative colorimetric detection of the neurotransmitters. Neurotransmitters 1, 2, and 4 are sensed with a detection limit of 2.5 × 10-6 M, whereas the detection limit for analyzing 3 corresponds to 2 × 10-5 M. The neurotransmitter-mediated growth of the Au-NPs is also used to probe the activity of tyrosinase. The later biocatalyst oxidizes tyrosine to L-DOPA that mediates the growth of the Au-NPs. The analysis of tyrosinase activity is important for detecting melanoma cells and Parkinson disease.
UR - http://www.scopus.com/inward/record.url?scp=15444363501&partnerID=8YFLogxK
U2 - 10.1021/ac048691v
DO - 10.1021/ac048691v
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C2 - 15762558
AN - SCOPUS:15444363501
SN - 0003-2700
VL - 77
SP - 1566
EP - 1571
JO - Analytical Chemistry
JF - Analytical Chemistry
IS - 6
ER -
