Down-regulation of mast cell responses through ITIM containing inhibitory receptors

Laila Karra, Francesca Levi-Schaffer*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

33 Scopus citations


The multiple cell types that comprise the immune system provide an efficient defense system against invading pathogens and micro-organisms. In general, immune cells are activated for disparate functions, such as proliferation, production and release of mediators and chemotaxis, as a result of interactions between ligands and their matching immunoreceptors. This in turn leads to the recruitment and activation of a cascade of second messengers, via their regulators/adaptors, that determine the net effect of the initial response. However, activation of cells of the immune system must be tightly regulated by a finely tuned interplay between activation and inhibition to avoid excessive or inappropriate responsiveness and to maintain homeostasis. Loss of inhibitory signals may disrupt this balance, leading to various pathological processes such as allergic and auto-immune diseases. In this chapter, we will discuss down-regulating mechanisms of mast cells focusing on immunoreceptor tyrosine-based inhibition motifs (ITIM)-containing inhibitory receptors (IR).

Original languageAmerican English
Title of host publicationMast Cell Biology
Subtitle of host publicationContemporary and Emerging Topics
EditorsAlasdair M. Gilfillan, Dean D. Metcalfe
Number of pages17
StatePublished - 2011

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598


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