Drinking induced by dextran and histamine: Relation to kidneys and renin

Yehuda Gutman*, Michael Krausz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Intravenous injection of dextran (M.W. 70,000) to rats caused an increased water intake which was accompanied by elevation of plasma renin activity (PRA). The thirst-inducing effect of dextran was abolished by nephrectomy but was unaffected by ureteral ligature. Dextran-induced thirst was blocked by propranolol and by diphenhydramine but the elevation of PRA caused by dextran was not reduced by either of these drugs. Histamine injected subcutaneously to rats increased water intake and elevated PRA. Histamine-induced thirst was only partly reduced after nephrectomy or following administration of propranolol but was completely abolished by diphenhydramine. The elevation of PRA by dextran outlasted the period of increased drinking. The mechanisms involved in the drinking induced by dextran with relation to the kidney, renin and site of action of various blockers are discussed.

Original languageEnglish
Pages (from-to)256-263
Number of pages8
JournalEuropean Journal of Pharmacology
Volume23
Issue number3
DOIs
StatePublished - Sep 1973

Keywords

  • Histamine Dextran
  • Hypovolemia
  • Nephrectomy
  • Propranolol
  • Renin
  • Thirst

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