Abstract
Intravenous injection of dextran (M.W. 70,000) to rats caused an increased water intake which was accompanied by elevation of plasma renin activity (PRA). The thirst-inducing effect of dextran was abolished by nephrectomy but was unaffected by ureteral ligature. Dextran-induced thirst was blocked by propranolol and by diphenhydramine but the elevation of PRA caused by dextran was not reduced by either of these drugs. Histamine injected subcutaneously to rats increased water intake and elevated PRA. Histamine-induced thirst was only partly reduced after nephrectomy or following administration of propranolol but was completely abolished by diphenhydramine. The elevation of PRA by dextran outlasted the period of increased drinking. The mechanisms involved in the drinking induced by dextran with relation to the kidney, renin and site of action of various blockers are discussed.
Original language | English |
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Pages (from-to) | 256-263 |
Number of pages | 8 |
Journal | European Journal of Pharmacology |
Volume | 23 |
Issue number | 3 |
DOIs | |
State | Published - Sep 1973 |
Keywords
- Histamine Dextran
- Hypovolemia
- Nephrectomy
- Propranolol
- Renin
- Thirst