Drosophila Ten-a is a maternal pair-rule and patterning gene

Nadya Rakovitsky, Yosef Buganim, Tomer Swissa, Yael Kinel-Tahan, Shirly Brenner, Malkiel A. Cohen, Anna Levine, Ron Wides*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The Ten-a gene of Drosophila melanogaster encodes several alternative variants of a full length member of the Odz/Tenm protein family. A number of Ten-a mutants created by inexact excisions of a resident P-element insertion are embryonic lethal, but show no pair-rule phenotype. In contrast, these mutants, and deficiencies removing Ten-a, do enhance the segmentation phenotype of a weak allele of the paralog gene odz (or Ten-m) to the odz amorphic phenotype. Germ line clone derived Ten-a- embryos display a pair-rule phenotype which phenocopies that of odz. Post segmentation eye patterning phenotypes of Ten-a mutants establish it as a pleiotropic patterning co-partner of odz.

Original languageAmerican English
Pages (from-to)911-924
Number of pages14
JournalMechanisms of Development
Issue number11-12
StatePublished - Nov 2007
Externally publishedYes


  • Metamerism
  • Odz/Tenm genes
  • Segmentation
  • Signal transduction


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