TY - JOUR
T1 - Drug delivery systems for the treatment of restenosis
AU - Chorny, Michael
AU - Fishbein, Ilia
AU - Golomb, Gershon
PY - 2000
Y1 - 2000
N2 - Attempts to achieve revascularization of coronary arteries blocked by atherosclerotic plaques are hampered by restenotic hyperproliferative response of the treated vessels. The uniform failure of clinical trials using systemic therapies to prevent restenosis has prompted development of methods for arterial drug delivery systems. This review describes technologies of polymeric-based, perivascular, and intraluminal drug and gene delivery systems. The critical assessment of controversies including drug and vehicle type, dose and release rate, and preclinical validation is reviewed.
AB - Attempts to achieve revascularization of coronary arteries blocked by atherosclerotic plaques are hampered by restenotic hyperproliferative response of the treated vessels. The uniform failure of clinical trials using systemic therapies to prevent restenosis has prompted development of methods for arterial drug delivery systems. This review describes technologies of polymeric-based, perivascular, and intraluminal drug and gene delivery systems. The critical assessment of controversies including drug and vehicle type, dose and release rate, and preclinical validation is reviewed.
KW - Controlled release
KW - Drug delivery systems
KW - Nanoparticles
KW - Polymeric-based drug delivery
KW - Restenosis
UR - http://www.scopus.com/inward/record.url?scp=0033918482&partnerID=8YFLogxK
U2 - 10.1615/critrevtherdrugcarriersyst.v17.i3.20
DO - 10.1615/critrevtherdrugcarriersyst.v17.i3.20
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C2 - 10868290
AN - SCOPUS:0033918482
SN - 0743-4863
VL - 17
SP - 249
EP - 284
JO - Critical Reviews in Therapeutic Drug Carrier Systems
JF - Critical Reviews in Therapeutic Drug Carrier Systems
IS - 3
ER -
