Drug exposure in pregnancy and heart defects

Ilan Matok, Anna Pupco, Gideon Koren*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Being the most common group of congenital malformations, congenital heart defects have often been investigated to rule out teratogenic effects by medicinal drugs and chemicals. Yet, the use of rigorous epidemiological methods has rejected such claims in many cases. We critically evaluate drugs believed to be associated with an increased risk of causing congenital heart defects, highlighting the debate and the practical implications of such associations.

Original languageAmerican English
Pages (from-to)20-24
Number of pages5
JournalJournal of Cardiovascular Pharmacology
Issue number1
StatePublished - Jul 2011
Externally publishedYes


  • cardiac birth defects
  • congenital malformations
  • drugs safety
  • pregnancy


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