Drug-induced ubiquitylation and degradation of ErbB receptor tyrosine kinases: Implications for cancer therapy

Keyphrases

• Tyrosine Kinase Inhibitor 100%
• ErbB2 100%
• Cancer Therapy 100%
• Ubiquitylation 100%
• Drug-induced 100%
• ErbB Receptor Tyrosine Kinase 100%
• Oncoprotein 66%
• Geldanamycin 66%
• CI-1033 66%
• Tyrosine Phosphorylation 33%
• Alkylation 33%
• Cysteine 33%
• Overexpression 33%
• Tumor 33%
• Therapeutic Strategies 33%
• Clinical Application 33%
• Human Epidermal Growth Factor Receptor 2 (HER2) 33%
• Endocytosis 33%
• ErbB Receptors 33%
• Chaperone 33%
• Stress-induced 33%
• Tumor Cell Proliferation 33%
• Heat Shock Protein 90 (Hsp90) 33%
• Inhibit Tumor 33%
• Molecular Chaperone 33%
• Degradation Pathway 33%
• Induced Degradation 33%
• Induced Mechanism 33%
• Human Malignancies 33%
• Selective Destruction 33%
• Irreversible Tyrosine Kinase Inhibitor 33%
• Human Therapeutics 33%
• Nucleotide Binding Site 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Protein Tyrosine Kinase 100%
• Protein Tyrosine Kinase Inhibitor 100%
• Malignant Neoplasm 100%
• Epidermal Growth Factor Receptor 100%
• Oncoprotein 50%
• Geldanamycin 50%
• Neoplasm 25%
• Tumor Growth 25%
• Phosphotransferase 25%
• Binding Site 25%
• Cysteine 25%
• Chaperone 25%
• Heat Shock Protein 90 25%