Drug interactions involving antiepileptic drugs: Assessment of the consistency among three drug compendia and FDA-approved labels

Dana Ekstein, Matanya Tirosh, Yonatan Eyal, Sara Eyal*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Interactions of antiepileptic drugs (AEDs) with other substances may lead to adverse effects and treatment failure. To avoid such interactions, clinicians often rely on drug interaction compendia. Our objective was to compare the concordance for twenty-two AEDs among three drug interaction compendia (Micromedex, Lexi-Interact, and Clinical Pharmacology) and the US Food and Drug Administration-approved product labels. For each AED, the overall concordance among data sources regarding existence of interactions and their classification was poor, with less than twenty percent of interactions listed in all four sources. Concordance among the three drug compendia decreased with the fraction of the drug excreted unchanged and was greater for established inducers of hepatic drug-metabolizing enzymes than for the drugs that are not inducers (R-square. =. 0.83, P<. 0.01). For interactions classified as contraindications, major, and severe, concordance among the four data sources was, in most cases, less than 30%. Prescribers should be aware of the differences between drug interaction sources of information for both older AEDs and newer AEDs, in particular for those AEDs which are not involved in hepatic enzyme-mediated interactions.

Original languageAmerican English
Pages (from-to)218-224
Number of pages7
JournalEpilepsy and Behavior
Volume44
DOIs
StatePublished - 1 Mar 2015

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Inc.

Keywords

  • Antiepileptic drugs
  • Compendia
  • Cytochrome P450
  • Drug information
  • Drug interactions

Fingerprint

Dive into the research topics of 'Drug interactions involving antiepileptic drugs: Assessment of the consistency among three drug compendia and FDA-approved labels'. Together they form a unique fingerprint.

Cite this