TY - JOUR
T1 - Drug-resistant pulmonary tuberculosis in Israel, a society of immigrants
T2 - 1985-1994
AU - Sosna, J.
AU - Shulimzon, T.
AU - Roznman, J.
AU - Lidgi, M.
AU - Lavy, A.
AU - Ben-Dov, I. Z.
AU - Ben-Dov, I.
PY - 1999/8
Y1 - 1999/8
N2 - SETTING AND OBJECTIVES: Drug-resistant tuberculosis was uncommon in Israel until 1985, when the waves of immigration began. We studied the incidence and clinical course of resistant pulmonary tuberculosis nationwide, DESIGN: Isolates of Mycobacterium tuberculosis between 1985 and 1994 were surveyed, Data on 150 patients with resistance and 110 patients with drug- sensitive disease were reviewed. Ethnic origin, type of resistance, radiological findings and outcome were analysed. RESULTS: In total, 16.7% of the isolates showed resistance to at least one drug; 58% had resistance to multiple drugs. In 67% of the patients the resistance was primary. Most patients were immigrants from the former USSR and from Ethiopia; none were Israeli-born Jews. Mortality with resistance was 10%, and was highest (14%) with multiple drug resistance. Mortality among drug-resistant cases was lowest (3%) among Ethiopian Jews. Cavities and extensive disease were more common with drug resistance. CONCLUSION: Drug resistance has become relatively common in Israel due to immigration from the former USSR and Ethiopia. It is more extensive radiologically and carries a poorer outcome.
AB - SETTING AND OBJECTIVES: Drug-resistant tuberculosis was uncommon in Israel until 1985, when the waves of immigration began. We studied the incidence and clinical course of resistant pulmonary tuberculosis nationwide, DESIGN: Isolates of Mycobacterium tuberculosis between 1985 and 1994 were surveyed, Data on 150 patients with resistance and 110 patients with drug- sensitive disease were reviewed. Ethnic origin, type of resistance, radiological findings and outcome were analysed. RESULTS: In total, 16.7% of the isolates showed resistance to at least one drug; 58% had resistance to multiple drugs. In 67% of the patients the resistance was primary. Most patients were immigrants from the former USSR and from Ethiopia; none were Israeli-born Jews. Mortality with resistance was 10%, and was highest (14%) with multiple drug resistance. Mortality among drug-resistant cases was lowest (3%) among Ethiopian Jews. Cavities and extensive disease were more common with drug resistance. CONCLUSION: Drug resistance has become relatively common in Israel due to immigration from the former USSR and Ethiopia. It is more extensive radiologically and carries a poorer outcome.
KW - Mortality
KW - Outcome
KW - Primary and secondary resistance
KW - Radiographic findings
UR - http://www.scopus.com/inward/record.url?scp=0032768801&partnerID=8YFLogxK
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C2 - 10460101
AN - SCOPUS:0032768801
SN - 1027-3719
VL - 3
SP - 689
EP - 694
JO - International Journal of Tuberculosis and Lung Disease
JF - International Journal of Tuberculosis and Lung Disease
IS - 8
ER -
