Drugs acting at TRPM7 channels inhibit seizure-like activity

Aytakin Khalil, Tawfeeq Shekh-Ahmad, Stjepana Kovac, Robert C. Wykes, F. David Horgen, Andrea Fleig, Matthew C. Walker*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Transient receptor potential cation subfamily M7 (TRPM7) channels are ion channels permeable to divalent cations. They are abundantly expressed with particularly high expression in the brain. Previous studies have highlighted the importance of TRPM7 channels in brain diseases such as stroke and traumatic brain injury, yet evidence for a role in seizures and epilepsy is lacking. Here, we show that carvacrol, a food additive that inhibits TRPM7 channels, and waixenicin A, a novel selective and potent TRPM7 inhibitor, completely suppressed seizure-like activity in rodent hippocampal-entorhinal brain slices exposed to pentylenetetrazole or low magnesium. These findings support inhibition of TRPM7 channels as a novel target for antiseizure medications.

Original languageAmerican English
Pages (from-to)1169-1174
Number of pages6
JournalEpilepsia Open
Volume8
Issue number3
DOIs
StatePublished - Sep 2023

Bibliographical note

Publisher Copyright:
© 2023 The Authors. Epilepsia Open published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.

Keywords

  • TRPM7
  • carvacrol
  • epilepsy
  • seizure
  • waixenicin A

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