Dual-modality fluorescence and full-field optical coherence microscopy for biomedical imaging applications

Egidijus Auksorius*, Yaron Bromberg, Ruta Motiejunaite, Alberto Pieretti, Linbo Liu, Emmanuel Coron, Jorge Aranda, Allan M. Goldstein, Brett E. Bouma, Andrius Kazlauskas, Guillermo J. Tearney

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Full-field optical coherence microscopy (FFOCM) is a high-resolution interferometric technique that is particularly attractive for biomedical imaging. Here we show that combining it with structured illumination fluorescence microscopy on one platform can increase its versatility since it enables co-localized registration of optically sectioned reflectance and fluorescence images. To demonstrate the potential of this dual modality, a fixed and labeled mouse retina was imaged. Results showed that both techniques can provide complementary information and therefore the system could potentially be useful for biomedical imaging applications.

Original languageAmerican English
Pages (from-to)661-666
Number of pages6
JournalBiomedical Optics Express
Volume3
Issue number3
DOIs
StatePublished - 1 Mar 2012
Externally publishedYes

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