Dual-modality fluorescence and full-field optical coherence microscopy for biomedical imaging applications

Egidijus Auksorius; Yaron Bromberg; Ruta Motiejunaite; Alberto Pieretti; Linbo Liu; Emmanuel Coron; Jorge Aranda; Allan M. Goldstein; Brett E. Bouma; Andrius Kazlauskas; Guillermo J. Tearney

doi:10.1364/BOE.3.000661

Dual-modality fluorescence and full-field optical coherence microscopy for biomedical imaging applications

Egidijus Auksorius^*, Yaron Bromberg, Ruta Motiejunaite, Alberto Pieretti, Linbo Liu, Emmanuel Coron, Jorge Aranda, Allan M. Goldstein, Brett E. Bouma, Andrius Kazlauskas, Guillermo J. Tearney

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Full-field optical coherence microscopy (FFOCM) is a high-resolution interferometric technique that is particularly attractive for biomedical imaging. Here we show that combining it with structured illumination fluorescence microscopy on one platform can increase its versatility since it enables co-localized registration of optically sectioned reflectance and fluorescence images. To demonstrate the potential of this dual modality, a fixed and labeled mouse retina was imaged. Results showed that both techniques can provide complementary information and therefore the system could potentially be useful for biomedical imaging applications.

Original language	English
Pages (from-to)	661-666
Number of pages	6
Journal	Biomedical Optics Express
Volume	3
Issue number	3
DOIs	https://doi.org/10.1364/BOE.3.000661
State	Published - 1 Mar 2012
Externally published	Yes

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AU - Auksorius, Egidijus

AU - Bromberg, Yaron

AU - Motiejunaite, Ruta

AU - Pieretti, Alberto

AU - Liu, Linbo

AU - Coron, Emmanuel

AU - Aranda, Jorge

AU - Goldstein, Allan M.

AU - Bouma, Brett E.

AU - Kazlauskas, Andrius

AU - Tearney, Guillermo J.

PY - 2012/3/1

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N2 - Full-field optical coherence microscopy (FFOCM) is a high-resolution interferometric technique that is particularly attractive for biomedical imaging. Here we show that combining it with structured illumination fluorescence microscopy on one platform can increase its versatility since it enables co-localized registration of optically sectioned reflectance and fluorescence images. To demonstrate the potential of this dual modality, a fixed and labeled mouse retina was imaged. Results showed that both techniques can provide complementary information and therefore the system could potentially be useful for biomedical imaging applications.

AB - Full-field optical coherence microscopy (FFOCM) is a high-resolution interferometric technique that is particularly attractive for biomedical imaging. Here we show that combining it with structured illumination fluorescence microscopy on one platform can increase its versatility since it enables co-localized registration of optically sectioned reflectance and fluorescence images. To demonstrate the potential of this dual modality, a fixed and labeled mouse retina was imaged. Results showed that both techniques can provide complementary information and therefore the system could potentially be useful for biomedical imaging applications.

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Dual-modality fluorescence and full-field optical coherence microscopy for biomedical imaging applications

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