TY - JOUR
T1 - dup(10q) Lacking α-satellite DNA in bone marrow cells of a patient with acute myeloid leukemia
AU - Abeliovich, Dvorah
AU - Yehuda, Orly
AU - Ben-Neriah, Susana
AU - Kapelushnik, Yosef
AU - Ben-Yehuda, Dina
PY - 1996/7/1
Y1 - 1996/7/1
N2 - A marker chromosome was identified in leukemic cells on an AML patient. The G-banding pattern resembled an i(10q), but its centromeric position was not clear; in some cells it had a telocentric shape, in others a metacentric or acentric shape. The origin of the marker chromosome was confirmed by FISH, using chromosome-10-specific painting. To determine the centromeric position, C-banding and α-satellite probes were applied in FISH, and none of them gave a positive signal. Despite the absence of the centromeric α-satellite sequences and the constricted feature of the centromere, the essential centromeric activity was retained in this chromosome, namely, the separation of sister chromatids in anaphase.
AB - A marker chromosome was identified in leukemic cells on an AML patient. The G-banding pattern resembled an i(10q), but its centromeric position was not clear; in some cells it had a telocentric shape, in others a metacentric or acentric shape. The origin of the marker chromosome was confirmed by FISH, using chromosome-10-specific painting. To determine the centromeric position, C-banding and α-satellite probes were applied in FISH, and none of them gave a positive signal. Despite the absence of the centromeric α-satellite sequences and the constricted feature of the centromere, the essential centromeric activity was retained in this chromosome, namely, the separation of sister chromatids in anaphase.
UR - http://www.scopus.com/inward/record.url?scp=0030200059&partnerID=8YFLogxK
U2 - 10.1016/0165-4608(95)00300-2
DO - 10.1016/0165-4608(95)00300-2
M3 - Article
C2 - 8689602
AN - SCOPUS:0030200059
SN - 0165-4608
VL - 89
SP - 1
EP - 6
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 1
ER -
