dup(10q) Lacking α-satellite DNA in bone marrow cells of a patient with acute myeloid leukemia

Dvorah Abeliovich; Orly Yehuda; Susana Ben-Neriah; Yosef Kapelushnik; Dina Ben-Yehuda

doi:10.1016/0165-4608(95)00300-2

dup(10q) Lacking α-satellite DNA in bone marrow cells of a patient with acute myeloid leukemia

Dvorah Abeliovich^*, Orly Yehuda, Susana Ben-Neriah, Yosef Kapelushnik, Dina Ben-Yehuda

^*Corresponding author for this work

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Abstract

A marker chromosome was identified in leukemic cells on an AML patient. The G-banding pattern resembled an i(10q), but its centromeric position was not clear; in some cells it had a telocentric shape, in others a metacentric or acentric shape. The origin of the marker chromosome was confirmed by FISH, using chromosome-10-specific painting. To determine the centromeric position, C-banding and α-satellite probes were applied in FISH, and none of them gave a positive signal. Despite the absence of the centromeric α-satellite sequences and the constricted feature of the centromere, the essential centromeric activity was retained in this chromosome, namely, the separation of sister chromatids in anaphase.

Original language	English
Pages (from-to)	1-6
Number of pages	6
Journal	Cancer Genetics and Cytogenetics
Volume	89
Issue number	1
DOIs	https://doi.org/10.1016/0165-4608(95)00300-2
State	Published - 1 Jul 1996
Externally published	Yes

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AU - Kapelushnik, Yosef

AU - Ben-Yehuda, Dina

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dup(10q) Lacking α-satellite DNA in bone marrow cells of a patient with acute myeloid leukemia

Abstract

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