TY - JOUR
T1 - Duration of spinal anaesthesia is determined by the partition coefficient of local anaesthetic
AU - Langerman, L.
AU - Golomb, E.
AU - Grant, G. J.
AU - Benita, S.
PY - 1994/4
Y1 - 1994/4
N2 - We have compared the duration of motor block produced by four local anaesthetics administered into a chronically implanted subarachnoid catheter in rabbits. Each group (n = 6) received four different doses of amethocaine, bupivacaine, lignocaine or procaine, and the duration of the resulting motor block was assessed. Dose-response curves were plotted for each drug. As a measure of activity of the anaesthetics, we used the dose of each drug required to produce block of 60-min duration (D60min) and the correlation between D60min and different drug properties was examined. An inverse linear correlation (r = 0.995; P < 0.01) was observed between log D60min and the log of the partition coefficient of the local anaesthetics. No correlation was found between the effect and degree of protein binding, pKa or molecular weight. These results suggest that, in spinal anaesthesia, the partition coefficient could be used as a predictor of the duration of anaesthetic action. (Br. J. Anaesth. 1994; 72: 456-459)
AB - We have compared the duration of motor block produced by four local anaesthetics administered into a chronically implanted subarachnoid catheter in rabbits. Each group (n = 6) received four different doses of amethocaine, bupivacaine, lignocaine or procaine, and the duration of the resulting motor block was assessed. Dose-response curves were plotted for each drug. As a measure of activity of the anaesthetics, we used the dose of each drug required to produce block of 60-min duration (D60min) and the correlation between D60min and different drug properties was examined. An inverse linear correlation (r = 0.995; P < 0.01) was observed between log D60min and the log of the partition coefficient of the local anaesthetics. No correlation was found between the effect and degree of protein binding, pKa or molecular weight. These results suggest that, in spinal anaesthesia, the partition coefficient could be used as a predictor of the duration of anaesthetic action. (Br. J. Anaesth. 1994; 72: 456-459)
KW - Anaesthetic techniques: subarachnoid
KW - Anaesthetics, local arnethocaine
KW - Anaesthetics, local bupivacaine
KW - Anaesthetics, local: lignocaine
KW - Anaesthetics, local: procaine
UR - http://www.scopus.com/inward/record.url?scp=0028222978&partnerID=8YFLogxK
U2 - 10.1093/bja/72.4.456
DO - 10.1093/bja/72.4.456
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C2 - 8155451
AN - SCOPUS:0028222978
SN - 0007-0912
VL - 72
SP - 456
EP - 459
JO - British Journal of Anaesthesia
JF - British Journal of Anaesthesia
IS - 4
ER -