TY - JOUR
T1 - Dynamic interactions of nuclear lamina proteins with chromatin and transcriptional machinery
AU - Mattout-Drubezki, A.
AU - Gruenbaum, Y.
PY - 2003/10
Y1 - 2003/10
N2 - The nuclear lamina is a filamentous nuclear structure intimately connected to the inner nuclear membrane. It is composed of lamins, which are also present in the nuclear interior, and lamin-associated proteins. The nuclear lamina is involved directly or indirectly in many nuclear activities, including DNA replication and transcription, nuclear and chromatin organization, cell cycle regulation, cell development and differentiation, nuclear migration and apoptosis. Mutations in nuclear lamina genes cause a wide range of heritable human diseases, the molecular mechanisms for which are not well understood. This review describes our current knowledge of interactions between nuclear lamina proteins and chromatin, chromatin-remodeling factors, specific transcription factors and RNA polymerase II transcription machinery. Recent studies provide new insights into the nature and regulation of these interactions and suggest additional roles for the nuclear lamina.
AB - The nuclear lamina is a filamentous nuclear structure intimately connected to the inner nuclear membrane. It is composed of lamins, which are also present in the nuclear interior, and lamin-associated proteins. The nuclear lamina is involved directly or indirectly in many nuclear activities, including DNA replication and transcription, nuclear and chromatin organization, cell cycle regulation, cell development and differentiation, nuclear migration and apoptosis. Mutations in nuclear lamina genes cause a wide range of heritable human diseases, the molecular mechanisms for which are not well understood. This review describes our current knowledge of interactions between nuclear lamina proteins and chromatin, chromatin-remodeling factors, specific transcription factors and RNA polymerase II transcription machinery. Recent studies provide new insights into the nature and regulation of these interactions and suggest additional roles for the nuclear lamina.
KW - BAF
KW - GCL
KW - Heterochromatin
KW - Lamin-associated proteins
KW - Lamins
KW - LEM-domain
KW - Transcriptional regulation
UR - http://www.scopus.com/inward/record.url?scp=0242383489&partnerID=8YFLogxK
U2 - 10.1007/s00018-003-3038-3
DO - 10.1007/s00018-003-3038-3
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???
C2 - 14618255
AN - SCOPUS:0242383489
SN - 1420-682X
VL - 60
SP - 2053
EP - 2063
JO - Cellular and Molecular Life Sciences
JF - Cellular and Molecular Life Sciences
IS - 10
ER -