Early effects of iodine on DNA synthesis in sulfur mustard-induced skin lesions

Berta Brodsky; Sheetal Trivedi; Shyamal Peddada; Norris Flagler; Uri Wormser; Abraham Nyska

doi:10.1007/s00204-005-0032-6

Early effects of iodine on DNA synthesis in sulfur mustard-induced skin lesions

Berta Brodsky, Sheetal Trivedi, Shyamal Peddada, Norris Flagler, Uri Wormser^*, Abraham Nyska

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Sulfur mustard (SM) is powerful alkylator and highly cytotoxic blisterogen in both humans and animals. This study in male guinea pigs shows that, at an early stage (5 h) after SM exposure, a marked increase occurred in epithelial nuclear vacuolation, epidermal thickening, and dermal acute inflammation. Topical iodine treatment reduced the severity of these parameters. The rate of DNA synthesis expressed by incorporation of bromodeoxyuridine was reduced upon topical treatment with iodine only or SM only by 46 and 72%, respectively. Iodine treatment following SM exposure exerted an effect similar to that of SM only, indicating that DNA synthesis is not directly involved in the mechanism of action of iodine-induced protection.

Original language	English
Pages (from-to)	212-216
Number of pages	5
Journal	Archives of Toxicology
Volume	80
Issue number	4
DOIs	https://doi.org/10.1007/s00204-005-0032-6
State	Published - Apr 2006

Keywords

DNA synthesis
Iodine
Skin lesions
Sulfur mustard

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00204-005-0032-6

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abstract = "Sulfur mustard (SM) is powerful alkylator and highly cytotoxic blisterogen in both humans and animals. This study in male guinea pigs shows that, at an early stage (5 h) after SM exposure, a marked increase occurred in epithelial nuclear vacuolation, epidermal thickening, and dermal acute inflammation. Topical iodine treatment reduced the severity of these parameters. The rate of DNA synthesis expressed by incorporation of bromodeoxyuridine was reduced upon topical treatment with iodine only or SM only by 46 and 72%, respectively. Iodine treatment following SM exposure exerted an effect similar to that of SM only, indicating that DNA synthesis is not directly involved in the mechanism of action of iodine-induced protection.",

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AU - Brodsky, Berta

AU - Trivedi, Sheetal

AU - Peddada, Shyamal

AU - Flagler, Norris

AU - Wormser, Uri

AU - Nyska, Abraham

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AB - Sulfur mustard (SM) is powerful alkylator and highly cytotoxic blisterogen in both humans and animals. This study in male guinea pigs shows that, at an early stage (5 h) after SM exposure, a marked increase occurred in epithelial nuclear vacuolation, epidermal thickening, and dermal acute inflammation. Topical iodine treatment reduced the severity of these parameters. The rate of DNA synthesis expressed by incorporation of bromodeoxyuridine was reduced upon topical treatment with iodine only or SM only by 46 and 72%, respectively. Iodine treatment following SM exposure exerted an effect similar to that of SM only, indicating that DNA synthesis is not directly involved in the mechanism of action of iodine-induced protection.

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Early effects of iodine on DNA synthesis in sulfur mustard-induced skin lesions

Abstract

Keywords

UN SDGs

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