Early Maladaptive Cardiovascular Responses are Associated with Mortality in a Porcine Model of Hemorrhagic Shock

Ruth Shaylor, Lilach Gavish, Gal Yaniv, Linn Wagnert-Avraham, Samuel David Gertz, Charles Weissman, Jacob Megreli, Gil Shimon, Ben Simon, Asaf Berman, Arik Eisenkraft*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Background:Hemorrhage is a leading cause of death on the battlefield. Current methods for predicting hemodynamic deterioration during hemorrhage are of limited accuracy and practicality. During a study of the effects of remote ischemic preconditioning in pigs that underwent hemorrhage, we noticed arrhythmias among all pigs that died before the end of the experiment but not among surviving pigs. The present study was designed to identify and characterize the early maladaptive hemodynamic responses (tachycardia in the presence of hypotension without a corresponding increase in cardiac index or mean arterial blood pressure) and their predictive power for early mortality in this experimental model.Methods:Controlled hemorrhagic shock was induced in 16 pigs. Hemodynamic parameters were monitored continuously for 7h following bleeding. Changes in cardiovascular and laboratory parameters were analyzed and compared between those that had arrhythmia and those that did not.Results:All animals had similar changes in parameters until the end of the bleeding phase. Six animals developed arrhythmias and died early, while 10 had no arrhythmias and survived longer than 6 h or until euthanasia. Unlike survivors, those that died did not compensate for cardiac output (CO), diastolic blood pressure (DBP), and stroke volume (SV). Oxygen delivery (DO2) and mixed venous saturation (SvO2) remained low in animals that had arrhythmia, while achieving certain measures of recuperation in animals that did not. Serum lactate increased earlier and continued to rise in all animals that developed arrhythmias. No significant differences in hemoglobin concentrations were observed between groups.Conclusions:Despite similar initial changes in variables, we found that low CO, DBP, SV, DO2, SvO2, and high lactate are predictive of death in this animal model. The results of this experimental study suggest that maladaptive responses across a range of cardiovascular parameters that begin early after hemorrhage may be predictive of impending death, particularly in situations where early resuscitative treatment may be delayed.

Original languageAmerican English
Pages (from-to)485-492
Number of pages8
JournalShock
Volume53
Issue number4
DOIs
StatePublished - 1 Apr 2020

Bibliographical note

Funding Information:
This study was supported in part by the IDF Medical Corps Grant numbers 4440520303 and 4440622654 and The Alexander Grass Foundation Fund for Research in Military Medicine, The Institute for Research in Military Medicine (IRMM), Faculty of Medicine, The Hebrew University of Jerusalem, Israel. Prof SDG is the Director of the Military Track of Medicine and The Institute for Research in Military Medicine, and the Brandman Foundation Professor of Cardiac and Pulmonary Diseases of The Faculty of Medicine, The Hebrew University of Jerusalem.

Publisher Copyright:
© 2020 Lippincott Williams and Wilkins. All rights reserved.

Keywords

  • Arrhythmia
  • compensatory response
  • death prediction
  • hemorrhage
  • poor outcome

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