Early phytocannabinoid chemistry to endocannabinoids and beyond

Raphael Mechoulam; Lumír O. Hanuš; Roger Pertwee; Allyn C. Howlett

doi:10.1038/nrn3811

Early phytocannabinoid chemistry to endocannabinoids and beyond

Raphael Mechoulam^*
, Lumír O. Hanuš
, Roger Pertwee
, Allyn C. Howlett

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Review article › peer-review

298 Scopus citations

Abstract

Isolation and structure elucidation of most of the major cannabinoid constituents-including Δ⁹ -tetrahydrocannabinol (Δ⁹ -THC), which is the principal psychoactive molecule in Cannabis sativa-was achieved in the 1960s and 1970s. It was followed by the identification of two cannabinoid receptors in the 1980s and the early 1990s and by the identification of the endocannabinoids shortly thereafter. There have since been considerable advances in our understanding of the endocannabinoid system and its function in the brain, which reveal potential therapeutic targets for a wide range of brain disorders.

Original language	English
Pages (from-to)	757-764
Number of pages	8
Journal	Nature Reviews Neuroscience
Volume	15
Issue number	11
DOIs	https://doi.org/10.1038/nrn3811
State	Published - 25 Nov 2014

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abstract = "Isolation and structure elucidation of most of the major cannabinoid constituents-including Δ9 -tetrahydrocannabinol (Δ9 -THC), which is the principal psychoactive molecule in Cannabis sativa-was achieved in the 1960s and 1970s. It was followed by the identification of two cannabinoid receptors in the 1980s and the early 1990s and by the identification of the endocannabinoids shortly thereafter. There have since been considerable advances in our understanding of the endocannabinoid system and its function in the brain, which reveal potential therapeutic targets for a wide range of brain disorders.",

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Early phytocannabinoid chemistry to endocannabinoids and beyond

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