TY - JOUR
T1 - Early 68GA-PSMA PET/MRI acquisition
T2 - assessment of lesion detectability and PET metrics in patients with prostate cancer undergoing same-day late PET/CT
AU - Domachevsky, L.
AU - Bernstine, H.
AU - Goldberg, N.
AU - Nidam, M.
AU - Stern, D.
AU - Sosna, J.
AU - Groshar, D.
N1 - Publisher Copyright:
© 2017 The Royal College of Radiologists
PY - 2017/11
Y1 - 2017/11
N2 - Aim To compare lesion detectability and positron-emission tomography (PET) metric measurements between early-PET/magnetic resonance imaging (MRI) acquisition and same-day PET/computed tomography (CT). Materials and methods The study was approved by the institutional review board and written informed consent was obtained from all patients. Twenty-one patients underwent non-time-of-flight (TOF) PET/MRI immediately following 68GA-prostate-specific membrane antigen (PSMA) tracer injection in two steps: firstly, early prostate PET/MRI (pPET/MRI) and early whole-body (WB) PET/MRI (wbPET/MR) followed by WB TOF PET/CT (wbPET/CT). Lesion detectability was compared between wbPET/MRI and wbPET/CT while PET metric measurements were compared between pPET/MR, wbPET/MRI, and wbPET/CT. Results Sixty-one and 63 lesions were found on wbPET/MRI and wbPET/CT, respectively (K=0.95, 95% confidence interval (CI)=0.89–1.0) with very good correlation between PET metric measurements (r=0.91; p=0.001). Bland–Altman plots demonstrated a mean percentage difference between wbPET/CT with wbPET/MRI of 34.4% with 95% limits of agreement (LOA) between –39% to 107.9% for metabolic tumour volume (MTV) and a mean difference of 30% with LOA between –13.4% to 73.4% for peak standardised uptake value (SUVpeak). Conclusion Early PET/MRI demonstrates very good lesion detectability agreement and correlation with PET metrics compared to same-day PET/CT. Nevertheless, LOA are far beyond the clinically acceptable range, and therefore, PET/CT and early PET/MRI metrics cannot be used interchangeably.
AB - Aim To compare lesion detectability and positron-emission tomography (PET) metric measurements between early-PET/magnetic resonance imaging (MRI) acquisition and same-day PET/computed tomography (CT). Materials and methods The study was approved by the institutional review board and written informed consent was obtained from all patients. Twenty-one patients underwent non-time-of-flight (TOF) PET/MRI immediately following 68GA-prostate-specific membrane antigen (PSMA) tracer injection in two steps: firstly, early prostate PET/MRI (pPET/MRI) and early whole-body (WB) PET/MRI (wbPET/MR) followed by WB TOF PET/CT (wbPET/CT). Lesion detectability was compared between wbPET/MRI and wbPET/CT while PET metric measurements were compared between pPET/MR, wbPET/MRI, and wbPET/CT. Results Sixty-one and 63 lesions were found on wbPET/MRI and wbPET/CT, respectively (K=0.95, 95% confidence interval (CI)=0.89–1.0) with very good correlation between PET metric measurements (r=0.91; p=0.001). Bland–Altman plots demonstrated a mean percentage difference between wbPET/CT with wbPET/MRI of 34.4% with 95% limits of agreement (LOA) between –39% to 107.9% for metabolic tumour volume (MTV) and a mean difference of 30% with LOA between –13.4% to 73.4% for peak standardised uptake value (SUVpeak). Conclusion Early PET/MRI demonstrates very good lesion detectability agreement and correlation with PET metrics compared to same-day PET/CT. Nevertheless, LOA are far beyond the clinically acceptable range, and therefore, PET/CT and early PET/MRI metrics cannot be used interchangeably.
UR - http://www.scopus.com/inward/record.url?scp=85023603251&partnerID=8YFLogxK
U2 - 10.1016/j.crad.2017.06.116
DO - 10.1016/j.crad.2017.06.116
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C2 - 28716214
AN - SCOPUS:85023603251
SN - 0009-9260
VL - 72
SP - 944
EP - 950
JO - Clinical Radiology
JF - Clinical Radiology
IS - 11
ER -