Ectopic discharge in injured nerves: comparison of trigeminal and somatic afferent

Michael Tal, Marshall Devor*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

88 Scopus citations

Abstract

Using the teased fiber recording method, we have compared pathophysiological properties of afferent axons injured in the infraorbital nerve (ION) vs the sciatic nerve in rats. Both myelinated and unmyelinated axons ending in ION neuromas produced much less ongoing discharge than those ending in sciatic nerve neuromas. Similarly, mechanosensitivity and acute injury discharge in ION neuromas were minimal. These differences may be related to the different spectrum of neuropathic symptomatology associated with nerve injury in the trigeminal vs the segmental innervation fields.

Original languageEnglish
Pages (from-to)148-151
Number of pages4
JournalBrain Research
Volume579
Issue number1
DOIs
StatePublished - 1 May 1992

Keywords

  • Ectopic discharge
  • Infraorbital nerve
  • Nerve injury
  • Neuroma
  • Pain
  • Trigeminal nerve

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