Effect of adhesive antioxidant enzymes on experimental colitis in the rat

Abraham Rubinstein*, Sigal Blau, Paul Bass, Ron Kohen

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review


The efficacy of the adhesive antioxidant enzymes obtained in the dinitrobenzenesulfonic acid (DNBS)-induced rat model was studied, along with the production of superoxide dismutase (SOD) and catalase. The catalase and SOD were cationized successfully while maintaining part of their activity. The positive net charge of the enzymes enabled them to adhere to the colonic mucosa of the rat. The native catalase and SOD were unable to treat experimental colitis in the rat, while the cationized catalase and SOD were efficient in treating the experimental colitis.

Original languageAmerican English
Pages (from-to)316-317
Number of pages2
JournalAmerican Chemical Society, Polymer Preprints, Division of Polymer Chemistry
Issue number1
StatePublished - Mar 1999
EventProceedings of the 1999 ACS Anaheim Meeting - Anaheim, CA, USA
Duration: 21 Mar 199925 Mar 1999


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