The efficacy of the adhesive antioxidant enzymes obtained in the dinitrobenzenesulfonic acid (DNBS)-induced rat model was studied, along with the production of superoxide dismutase (SOD) and catalase. The catalase and SOD were cationized successfully while maintaining part of their activity. The positive net charge of the enzymes enabled them to adhere to the colonic mucosa of the rat. The native catalase and SOD were unable to treat experimental colitis in the rat, while the cationized catalase and SOD were efficient in treating the experimental colitis.
|Original language||American English|
|Number of pages||2|
|Journal||American Chemical Society, Polymer Preprints, Division of Polymer Chemistry|
|State||Published - Mar 1999|
|Event||Proceedings of the 1999 ACS Anaheim Meeting - Anaheim, CA, USA|
Duration: 21 Mar 1999 → 25 Mar 1999