TY - JOUR
T1 - Effect of adhesive antioxidant enzymes on experimental colitis in the rat
AU - Rubinstein, Abraham
AU - Blau, Sigal
AU - Bass, Paul
AU - Kohen, Ron
PY - 1999/3
Y1 - 1999/3
N2 - The efficacy of the adhesive antioxidant enzymes obtained in the dinitrobenzenesulfonic acid (DNBS)-induced rat model was studied, along with the production of superoxide dismutase (SOD) and catalase. The catalase and SOD were cationized successfully while maintaining part of their activity. The positive net charge of the enzymes enabled them to adhere to the colonic mucosa of the rat. The native catalase and SOD were unable to treat experimental colitis in the rat, while the cationized catalase and SOD were efficient in treating the experimental colitis.
AB - The efficacy of the adhesive antioxidant enzymes obtained in the dinitrobenzenesulfonic acid (DNBS)-induced rat model was studied, along with the production of superoxide dismutase (SOD) and catalase. The catalase and SOD were cationized successfully while maintaining part of their activity. The positive net charge of the enzymes enabled them to adhere to the colonic mucosa of the rat. The native catalase and SOD were unable to treat experimental colitis in the rat, while the cationized catalase and SOD were efficient in treating the experimental colitis.
UR - http://www.scopus.com/inward/record.url?scp=0033092659&partnerID=8YFLogxK
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AN - SCOPUS:0033092659
SN - 0032-3934
VL - 40
SP - 316
EP - 317
JO - American Chemical Society, Polymer Preprints, Division of Polymer Chemistry
JF - American Chemical Society, Polymer Preprints, Division of Polymer Chemistry
IS - 1
T2 - Proceedings of the 1999 ACS Anaheim Meeting
Y2 - 21 March 1999 through 25 March 1999
ER -