Abstract
Spike activity in dorsal root ganglion (DRG) neurons depolarizes passive neighbors that share the same ganglion. We asked whether age or prior nerve injury affect this 'cross-depolarization' signal. Intracellular recordings made from excised DRGs in vitro revealed that the prevalence and duration of cross-depolarization were no greater in adult than in young rats, and that its amplitude was significantly smaller in adults. The amplitude of cross- depolarization was not affected by nerve injury. The decrease in membrane input resistance (R(in)) observed during cross-depolarization was less than that expected from equivalent depolarization alone. This affirms prior evidence that the neural process underlying cross-depolarization causes a net increase in R(in).
Original language | English |
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Pages (from-to) | 95-98 |
Number of pages | 4 |
Journal | Neuroscience Letters |
Volume | 259 |
Issue number | 2 |
DOIs | |
State | Published - 8 Jan 1999 |
Keywords
- Cross-depolarization
- Dorsal root ganglion
- Nerve injury
- Non-synaptic coupling
- Pain