Effect of age and nerve injury on cross-excitation among sensory neurons in rat dorsal root ganglia

Chang Ning Liu, Ron Amir, Marshall Devor*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Spike activity in dorsal root ganglion (DRG) neurons depolarizes passive neighbors that share the same ganglion. We asked whether age or prior nerve injury affect this 'cross-depolarization' signal. Intracellular recordings made from excised DRGs in vitro revealed that the prevalence and duration of cross-depolarization were no greater in adult than in young rats, and that its amplitude was significantly smaller in adults. The amplitude of cross- depolarization was not affected by nerve injury. The decrease in membrane input resistance (R(in)) observed during cross-depolarization was less than that expected from equivalent depolarization alone. This affirms prior evidence that the neural process underlying cross-depolarization causes a net increase in R(in).

Original languageEnglish
Pages (from-to)95-98
Number of pages4
JournalNeuroscience Letters
Volume259
Issue number2
DOIs
StatePublished - 8 Jan 1999

Keywords

  • Cross-depolarization
  • Dorsal root ganglion
  • Nerve injury
  • Non-synaptic coupling
  • Pain

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