Effect of cholesterol-rich diet on the susceptibility of rodent malarial parasites to chloroquine chemotherapy

H. Ginsburg*, I. Landau, D. Baccam

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Mice were fed a cholesterol-rich diet and then subsequently infected with chloroquine-sensitive strains of either Plasmodium berghei or P. chabaudi. Chloroquine therapy, which was started 24 hours post-infection and continued for 3-4 days, was significantly less effective in cholesterol-fed animals compared to controls. The consequences of these findings to the resistance of P. falciparum in man to chloroquine, are discussed.

Original languageEnglish
Pages (from-to)7-10
Number of pages4
JournalLife Sciences
Volume42
Issue number1
DOIs
StatePublished - 1988

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