Abstract
Mice were fed a cholesterol-rich diet and then subsequently infected with chloroquine-sensitive strains of either Plasmodium berghei or P. chabaudi. Chloroquine therapy, which was started 24 hours post-infection and continued for 3-4 days, was significantly less effective in cholesterol-fed animals compared to controls. The consequences of these findings to the resistance of P. falciparum in man to chloroquine, are discussed.
Original language | English |
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Pages (from-to) | 7-10 |
Number of pages | 4 |
Journal | Life Sciences |
Volume | 42 |
Issue number | 1 |
DOIs | |
State | Published - 1988 |