Effect of cholesterol-rich diet on the susceptibility of rodent malarial parasites to chloroquine chemotherapy

H. Ginsburg; I. Landau; D. Baccam

doi:10.1016/0024-3205(88)90618-2

Effect of cholesterol-rich diet on the susceptibility of rodent malarial parasites to chloroquine chemotherapy

H. Ginsburg^*
, I. Landau
, D. Baccam

^*Corresponding author for this work

Alexander Silberman Institute of Life Sciences

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Mice were fed a cholesterol-rich diet and then subsequently infected with chloroquine-sensitive strains of either Plasmodium berghei or P. chabaudi. Chloroquine therapy, which was started 24 hours post-infection and continued for 3-4 days, was significantly less effective in cholesterol-fed animals compared to controls. The consequences of these findings to the resistance of P. falciparum in man to chloroquine, are discussed.

Original language	English
Pages (from-to)	7-10
Number of pages	4
Journal	Life Sciences
Volume	42
Issue number	1
DOIs	https://doi.org/10.1016/0024-3205(88)90618-2
State	Published - 1988

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10.1016/0024-3205(88)90618-2

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title = "Effect of cholesterol-rich diet on the susceptibility of rodent malarial parasites to chloroquine chemotherapy",

abstract = "Mice were fed a cholesterol-rich diet and then subsequently infected with chloroquine-sensitive strains of either Plasmodium berghei or P. chabaudi. Chloroquine therapy, which was started 24 hours post-infection and continued for 3-4 days, was significantly less effective in cholesterol-fed animals compared to controls. The consequences of these findings to the resistance of P. falciparum in man to chloroquine, are discussed.",

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AU - Ginsburg, H.

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AB - Mice were fed a cholesterol-rich diet and then subsequently infected with chloroquine-sensitive strains of either Plasmodium berghei or P. chabaudi. Chloroquine therapy, which was started 24 hours post-infection and continued for 3-4 days, was significantly less effective in cholesterol-fed animals compared to controls. The consequences of these findings to the resistance of P. falciparum in man to chloroquine, are discussed.

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Effect of cholesterol-rich diet on the susceptibility of rodent malarial parasites to chloroquine chemotherapy

Abstract

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