Effect of early and late light exposure on the inherited retinal degeneration in rats

M. Kaitz; E. Auerbach

doi:10.1016/0014-4835(78)90104-5

Effect of early and late light exposure on the inherited retinal degeneration in rats

M. Kaitz^*, E. Auerbach

^*Corresponding author for this work

Department of Psychology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The inherited retinal dystrophy of RCS rats is slowed by maintaining the animals from birth in total darkness. Adult dystrophic rats raised in darkness from birth show nearly four times the ERG amplitude of animals kept in cyclic light conditions. Light deprivation, however, need not begin at birth for the full benefit of the treatment to occur. Rats reared in cyclic light and then transferred to darkness at 15-29 days of age show ERGs in adult-hood equal to animals raised in darkness from birth. Early dark rearing for as long as 45 days does not protect the retina from effects of subsequent light exposure as measured by ERG amplitude. Thus, early rearing conditions neither permanently damage nor permanently protect the dystrophic retina of the RCS rat.

Original language	English
Pages (from-to)	699-704
Number of pages	6
Journal	Experimental Eye Research
Volume	26
Issue number	6
DOIs	https://doi.org/10.1016/0014-4835(78)90104-5
State	Published - Jun 1978

Keywords

dystrophic rats
light damage
light deprivation
retinitis pigmentosa

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10.1016/0014-4835(78)90104-5

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abstract = "The inherited retinal dystrophy of RCS rats is slowed by maintaining the animals from birth in total darkness. Adult dystrophic rats raised in darkness from birth show nearly four times the ERG amplitude of animals kept in cyclic light conditions. Light deprivation, however, need not begin at birth for the full benefit of the treatment to occur. Rats reared in cyclic light and then transferred to darkness at 15-29 days of age show ERGs in adult-hood equal to animals raised in darkness from birth. Early dark rearing for as long as 45 days does not protect the retina from effects of subsequent light exposure as measured by ERG amplitude. Thus, early rearing conditions neither permanently damage nor permanently protect the dystrophic retina of the RCS rat.",

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AB - The inherited retinal dystrophy of RCS rats is slowed by maintaining the animals from birth in total darkness. Adult dystrophic rats raised in darkness from birth show nearly four times the ERG amplitude of animals kept in cyclic light conditions. Light deprivation, however, need not begin at birth for the full benefit of the treatment to occur. Rats reared in cyclic light and then transferred to darkness at 15-29 days of age show ERGs in adult-hood equal to animals raised in darkness from birth. Early dark rearing for as long as 45 days does not protect the retina from effects of subsequent light exposure as measured by ERG amplitude. Thus, early rearing conditions neither permanently damage nor permanently protect the dystrophic retina of the RCS rat.

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KW - retinitis pigmentosa

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Effect of early and late light exposure on the inherited retinal degeneration in rats

Abstract

Keywords

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