Effect of Hydrolyzed Formaldehyde-treated RNA on Neoplastic and Normal Human Cells

M. Y. Feldman; Henny Balabanova; Uriel Bachrach; Michael Pyshnov

Effect of Hydrolyzed Formaldehyde-treated RNA on Neoplastic and Normal Human Cells

M. Y. Feldman
, Henny Balabanova
, Uriel Bachrach
, Michael Pyshnov

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Alkaline hydrolysate of dialyzed formaldehyde-treated RNA, in which 39% of purine nucleotides are modified to methylene bis derivatives (R—CH₂—R‘), displays cytotoxic activity toward cultured human tumor cells. The alkaline hydrolysate of dialyzed formaldehyde-treated RNA is substantially less toxic to normal human embryonic cells. There is a correlation between the cytotoxic effect and cell growth rate, which has been traced by quantitative tests.

Original language	English
Pages (from-to)	501-506
Number of pages	6
Journal	Cancer Research
Volume	37
Issue number	2
State	Published - Feb 1977

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Cite this

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abstract = "Alkaline hydrolysate of dialyzed formaldehyde-treated RNA, in which 39\% of purine nucleotides are modified to methylene bis derivatives (R—CH2—R{\textquoteleft}), displays cytotoxic activity toward cultured human tumor cells. The alkaline hydrolysate of dialyzed formaldehyde-treated RNA is substantially less toxic to normal human embryonic cells. There is a correlation between the cytotoxic effect and cell growth rate, which has been traced by quantitative tests.",

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AB - Alkaline hydrolysate of dialyzed formaldehyde-treated RNA, in which 39% of purine nucleotides are modified to methylene bis derivatives (R—CH2—R‘), displays cytotoxic activity toward cultured human tumor cells. The alkaline hydrolysate of dialyzed formaldehyde-treated RNA is substantially less toxic to normal human embryonic cells. There is a correlation between the cytotoxic effect and cell growth rate, which has been traced by quantitative tests.

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Effect of Hydrolyzed Formaldehyde-treated RNA on Neoplastic and Normal Human Cells

Abstract

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