Effect of linseed oil ingestion on plasma lipid fatty acid composition and platelet aggregability in healthy volunteers

P. Budowski; Naomi Trostler; M. Lupo; N. Vaisman; A. Eldor

doi:10.1016/S0271-5317(84)80020-2

Effect of linseed oil ingestion on plasma lipid fatty acid composition and platelet aggregability in healthy volunteers

P. Budowski^*
, Naomi Trostler
, M. Lupo
, N. Vaisman
, A. Eldor

^*Corresponding author for this work

Institute of Biochemistry, Food Science and Nutrition

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Eight healthy volunteers ingested 60 ml linseed oil over a period of six weeks. Icosapentaenoic acid increased in plasma triglycerides (TG), phospholipids (PL) and cholesteryl esters (CE) but did not exceed mean values of 2%. α-Linolenic acid rose markedly in TG, linoleic acid decreased in TG and CE, and arachidonic acid decreased in PL and CE. Two additional subjects on a similar regimen underwent blood platelet aggregability tests by the collagen threshold procedure. In both cases a striking decrease in platelet sensitivity to collagen was observed. The results show that linseed oil affects the polyunsaturated fatty acid profile of plasma lipids and suggest a possible alteration of platelet aggregability.

Original language	English
Pages (from-to)	343-346
Number of pages	4
Journal	Nutrition Research
Volume	4
Issue number	2
DOIs	https://doi.org/10.1016/S0271-5317(84)80020-2
State	Published - 1984

Keywords

Linseed oil
plasma lipids
platelet aggregation

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10.1016/S0271-5317(84)80020-2

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title = "Effect of linseed oil ingestion on plasma lipid fatty acid composition and platelet aggregability in healthy volunteers",

abstract = "Eight healthy volunteers ingested 60 ml linseed oil over a period of six weeks. Icosapentaenoic acid increased in plasma triglycerides (TG), phospholipids (PL) and cholesteryl esters (CE) but did not exceed mean values of 2\%. α-Linolenic acid rose markedly in TG, linoleic acid decreased in TG and CE, and arachidonic acid decreased in PL and CE. Two additional subjects on a similar regimen underwent blood platelet aggregability tests by the collagen threshold procedure. In both cases a striking decrease in platelet sensitivity to collagen was observed. The results show that linseed oil affects the polyunsaturated fatty acid profile of plasma lipids and suggest a possible alteration of platelet aggregability.",

keywords = "Linseed oil, plasma lipids, platelet aggregation",

author = "P. Budowski and Naomi Trostler and M. Lupo and N. Vaisman and A. Eldor",

year = "1984",

doi = "10.1016/S0271-5317(84)80020-2",

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T1 - Effect of linseed oil ingestion on plasma lipid fatty acid composition and platelet aggregability in healthy volunteers

AU - Budowski, P.

AU - Trostler, Naomi

AU - Lupo, M.

AU - Vaisman, N.

AU - Eldor, A.

PY - 1984

Y1 - 1984

N2 - Eight healthy volunteers ingested 60 ml linseed oil over a period of six weeks. Icosapentaenoic acid increased in plasma triglycerides (TG), phospholipids (PL) and cholesteryl esters (CE) but did not exceed mean values of 2%. α-Linolenic acid rose markedly in TG, linoleic acid decreased in TG and CE, and arachidonic acid decreased in PL and CE. Two additional subjects on a similar regimen underwent blood platelet aggregability tests by the collagen threshold procedure. In both cases a striking decrease in platelet sensitivity to collagen was observed. The results show that linseed oil affects the polyunsaturated fatty acid profile of plasma lipids and suggest a possible alteration of platelet aggregability.

AB - Eight healthy volunteers ingested 60 ml linseed oil over a period of six weeks. Icosapentaenoic acid increased in plasma triglycerides (TG), phospholipids (PL) and cholesteryl esters (CE) but did not exceed mean values of 2%. α-Linolenic acid rose markedly in TG, linoleic acid decreased in TG and CE, and arachidonic acid decreased in PL and CE. Two additional subjects on a similar regimen underwent blood platelet aggregability tests by the collagen threshold procedure. In both cases a striking decrease in platelet sensitivity to collagen was observed. The results show that linseed oil affects the polyunsaturated fatty acid profile of plasma lipids and suggest a possible alteration of platelet aggregability.

KW - Linseed oil

KW - plasma lipids

KW - platelet aggregation

UR - https://www.scopus.com/pages/publications/0021355435

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DO - 10.1016/S0271-5317(84)80020-2

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AN - SCOPUS:0021355435

SN - 0271-5317

VL - 4

SP - 343

EP - 346

JO - Nutrition Research

JF - Nutrition Research

IS - 2

ER -

Effect of linseed oil ingestion on plasma lipid fatty acid composition and platelet aggregability in healthy volunteers

Abstract

Keywords

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