Effect of lithium treatment on microsomal ATPase activity in several tissues

1. 1. Treatment with lithium chloride (2 mmol/kg. daily for 14 days) in the rat did not affect Mg⁺⁺-ATPase or (Na++K⁺)-dependent ATPase in the brain-stem, cortex, extrapyramidal nuclei, adrenal glands, or mucosa of the small intestine. 2. 2. Microsomal ATPase in the salivary glands increased under lithium: in the parotid (Na⁺+K⁺)-dependent ATPase increased while in the submaxillary gland the Mg⁺⁺-ATPase activity was elevated. 3. 3. In the mucosa of the colon Mg⁺⁺-ATPase was elevated and (Na⁺+K⁺)-dependent ATPase was reduced after treatment with lithium.